دورية أكاديمية
Frontotemporal dementia is the leading cause of “true” A−/T+ profiles defined with Aβ42/40 ratio
| العنوان: | Frontotemporal dementia is the leading cause of “true” A−/T+ profiles defined with Aβ42/40 ratio |
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| المؤلفون: | Hélène Pouclet‐Courtemanche, Tri‐Bao Nguyen, Emilie Skrobala, Claire Boutoleau‐Bretonnière, Florence Pasquier, Elodie Bouaziz‐Amar, Edith Bigot‐Corbel, Susanna Schraen, Julien Dumurgier, Claire Paquet, Thibaud Lebouvier |
| المصدر: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 161-169 (2019) |
| بيانات النشر: | Wiley |
| سنة النشر: | 2019 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Alzheimer's disease, Cerebrospinal fluid biomarkers, Aβ42/40 ratio, Aβ42/Aβ40 ratio, Frontotemporal dementia, Suspected non Alzheimer's disease pathology (SNAP), Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6 |
| الوصف: | Introduction Patients with positive tauopathy but negative Aβ42 (A−T+) in the cerebrospinal fluid (CSF) represent a diagnostic challenge. The Aβ42/40 ratio supersedes Aβ42 and reintegrates “false” A−T+ patients into the Alzheimer's disease spectrum. However, the biomarker and clinical characteristics of “true” and “false” A−T+ patients remain elusive. Methods Among the 509 T+N+ patients extracted from the databases of three memory clinics, we analyzed T+N+ patients with normal Aβ42 and compared “false” A−T+ with abnormal Aβ42/40 ratio and “true” A−T+ patients with normal Aβ42/40 ratio, before CSF analysis and at follow‐up. Results 24.9% of T+N+ patients had normal Aβ42 levels. Among them, 42.7% were “true” A−T+. “True” A−T+ had lower CSF tauP181 than “false” A−T+ patients. 48.0% of “true” A−T+ patients were diagnosed with frontotemporal lobar degeneration before CSF analysis and 64.0% at follow‐up, as compared with 6% in the “false” A−T+ group (P < .0001). Discussion Frontotemporal lobar degeneration is probably the main cause of “true” A−T+ profiles. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2352-8729 |
| العلاقة: | https://doi.org/10.1016/j.dadm.2019.01.001Test; https://doaj.org/toc/2352-8729Test; https://doaj.org/article/b451a21342644f32b03913fd70713b37Test |
| DOI: | 10.1016/j.dadm.2019.01.001 |
| الإتاحة: | https://doi.org/10.1016/j.dadm.2019.01.001Test https://doaj.org/article/b451a21342644f32b03913fd70713b37Test |
| رقم الانضمام: | edsbas.30DD68B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23528729 |
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| DOI: | 10.1016/j.dadm.2019.01.001 |