Tumor necrosis factor alpha promoter polymorphism at position -238 is associated with chronic active hepatitis C infection
| العنوان: | Tumor necrosis factor alpha promoter polymorphism at position -238 is associated with chronic active hepatitis C infection |
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| المؤلفون: | Christian Rittner, Peter M. Schneider, Karl-H. Meyer zum Büschenfelde, Thomas Höhler, Anke Kruger, G. Gerken |
| المصدر: | Journal of Medical Virology. 54:173-177 |
| بيانات النشر: | Wiley, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Male, Linkage disequilibrium, Genotype, Hepatitis C virus, Hepacivirus, Human leukocyte antigen, medicine.disease_cause, Gene Frequency, Virology, medicine, Humans, Prospective Studies, Allele, Promoter Regions, Genetic, Alleles, Hepatitis, Polymorphism, Genetic, biology, Tumor Necrosis Factor-alpha, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Promoter, Hepatitis C, Hepatitis C, Chronic, medicine.disease, biology.organism_classification, Infectious Diseases, Immunology, Female |
| الوصف: | Tumor necrosis factor alpha (TNF-alpha) is involved in the pathogenesis of chronic hepatitis C virus infection. The gene for TNF-alpha is encoded in the major histocompatibility locus (MHC). Two polymorphisms at positions -308 and -238 in the TNF-alpha promoter region might influence TNF-alpha expression. These promoter polymorphisms have been linked previously to a number of infectious diseases. TNF-alpha promoter polymorphisms at positions -238 and -308 were studied by DNA sequencing and sequence-specific oligonucleotide hybridization in 82 individuals with chronic hepatitis C and 99 control subjects. Subjects had been HLA class I and class II typed in a previous study. The frequency of the TNF238.2 promoter allele was significantly higher in the hepatitis C group (18.7%) compared to the controls (3.5%; P < 0.0001; pcorr < 0.009). No significant differences in the frequency of the TNF308.2 allele were observed between patients and controls. The increased frequency of the TNF238.2 allele could not be explained by linkage disequilibrium to HLA-B or -DR genes. These findings show an association between the TNF238.2 promoter variant and chronic active hepatitis C. They suggest that this polymorphism or a linked gene may be a host factor contributing to the development of chronic active hepatitis C. |
| تدمد: | 1096-9071 0146-6615 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae1f98bba63bc370ba8a6de5db020d2Test https://doi.org/10.1002Test/(sici)1096-9071(199803)54:3<173::aid-jmv5>3.0.co;2-2 |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1ae1f98bba63bc370ba8a6de5db020d2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969071 01466615 |
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