Role of High‐Throughput Electrophysiology in Drug Discovery
| العنوان: | Role of High‐Throughput Electrophysiology in Drug Discovery |
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| المؤلفون: | Chang Liu, Tianbo Li, Jun Chen |
| المصدر: | Current Protocols in Pharmacology. 87 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Patch-Clamp Techniques, Computer science, Drug discovery, General Medicine, Computational biology, Bottleneck, Electrophysiological Phenomena, High-Throughput Screening Assays, 03 medical and health sciences, Electrophysiology, 030104 developmental biology, 0302 clinical medicine, Automated patch clamp, Ion channel activity, Drug Discovery, Patch clamp, Throughput (business), 030217 neurology & neurosurgery, Ion channel |
| الوصف: | Due to their important physiological functions, ion channels are key therapeutic targets for a variety of disorders. However, electrophysiological assessment of ion channel activity is technically challenging and has been a bottleneck in the discovery of drugs that modulate channel function. To address this issue, automated patch clamp platforms have been developed with improved throughput and broader applications. An overview of the current status of high-throughput electrophysiology and its applications in drug discovery is provided. © 2019 The Authors. |
| تدمد: | 1934-8290 1934-8282 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf04d0099c93029590f96ae0c8d2036Test https://doi.org/10.1002/cpph.69Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....abf04d0099c93029590f96ae0c8d2036 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19348290 19348282 |
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