Metabolic Changes Associated with Vacuolation in Murine Models of Scrapie usingIn Vitro1H-NMR Spectroscopy
| العنوان: | Metabolic Changes Associated with Vacuolation in Murine Models of Scrapie usingIn Vitro1H-NMR Spectroscopy |
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| المؤلفون: | Steve C.R. Williams, Angela Chong, Alun Williams, James Hope, Yuen-Li Chung, Jimmy D. Bell |
| المصدر: | NMR in Biomedicine. 9:359-363 |
| بيانات النشر: | Wiley, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Ratón, Neurodegeneration, Scrapie, Metabolism, Biology, medicine.disease, Creatine, Molecular biology, In vitro, chemistry.chemical_compound, chemistry, Gliosis, medicine, Molecular Medicine, Choline, Radiology, Nuclear Medicine and imaging, medicine.symptom, Spectroscopy |
| الوصف: | In this study, metabolic changes in the 79A/C3H, ME7/VM, ME7/C3H, 87V/VM and 22A/SV scrapie mouse models were investigated during the clinical phase of the disease, using in vitro proton nuclear magnetic resonance spectroscopy. N-acetyl-aspartate was found to be significantly reduced in infected mice of the ME7/ C3H (40% reduction), ME7/VM (26%) and 79A/C3H (17%) models when compared to control mice, but not in the 87V/VM and 22A/SV models. The concentration of choline containing compounds and creatine remain unchanged in all models when compared with control murine brains. The level of N-acetyl-aspartate reduction correlated with the extent of grey-matter brain vacuolation. The levels of myo-inositol were found to be significantly increased in the ME7/VM (143%) and 79A/C3H (132%) models only and no significant changes were observed in the ME7/C3H, 87V/VM and 22A/SV models. These changes did not correspond to the severity of gliosis. |
| تدمد: | 1099-1492 0952-3480 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::4c17a9876fe439ac424dd364e7dd4cbdTest https://doi.org/10.1002Test/(sici)1099-1492(199612)9:8<359::aid-nbm428>3.0.co;2-d |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........4c17a9876fe439ac424dd364e7dd4cbd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10991492 09523480 |
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