دورية أكاديمية
Retinal vessel changes in pulmonary arterial hypertension
| العنوان: | Retinal vessel changes in pulmonary arterial hypertension |
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| المؤلفون: | Mariana DuPont, Savanna Lambert, Antonio Rodriguez‐Martin, Okaeri Hernandez, Mark Lagatuz, Taygan Yilmaz, Andrew Foderaro, Grayson L. Baird, Patricia Parsons‐Wingerter, Tim Lahm, Maria B. Grant, Corey E. Ventetuolo |
| المصدر: | Pulmonary Circulation, Vol 12, Iss 1, Pp n/a-n/a (2022) |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | hemodynamics, microvascular, pulmonary vascular disease, retina, VESGEN, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the respiratory system, RC705-779 |
| الوصف: | Abstract Pulmonary arterial hypertension (PAH) is classically considered an isolated small vessel vasculopathy of the lungs with peripheral pulmonary vascular obliteration. Systemic manifestations of PAH are increasingly acknowledged, but data remain limited. We hypothesized that retinal vascular changes occur in PAH. PAH subjects underwent retinal fluorescein angiography (FA) and routine disease severity measures were collected from the medical record. FA studies were analyzed using VESsel GENerational Analysis (VESGEN), a noninvasive, user‐interactive computer software that assigns branching generation to large and small vessels. FAs from controls (n = 8) and PAH subjects (n = 9) were compared. The tortuosity of retinal arteries was higher in PAH subjects compared to unmatched controls (1.17, 95% confidence interval: [1.14, 1.20] in PAH vs. 1.13, 95% CI: [1.12, 1.14] in controls, p = 0.01). Venous tortuosity was higher and more variable in PAH (1.17, 95% CI: [1.14, 1.20]) compared to controls (1.13, 95% CI: [1.12, 1.15]), p = 0.02. PAH subjects without connective tissue disease had the highest degree of retinal tortuosity relative to controls (arterial, p = 0.01; venous, p = 0.03). Younger PAH subjects had greater retinal arterial tortuosity, which attenuated with age and was not observed in controls. Retinal vascular parameters correlated with some clinical measures of disease in PAH subjects. In conclusion, PAH subjects exhibit higher retinal vascular tortuosity. Retinal vascular changes may track with pulmonary vascular disease progression. Use of FA and VESGEN may facilitate early, noninvasive detection of PAH. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-8940 |
| العلاقة: | https://doaj.org/toc/2045-8940Test |
| DOI: | 10.1002/pul2.12035 |
| الوصول الحر: | https://doaj.org/article/692067a621a946f5ad2018c46d95fa04Test |
| رقم الانضمام: | edsdoj.692067a621a946f5ad2018c46d95fa04 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20458940 |
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| DOI: | 10.1002/pul2.12035 |