Non‐Invasive Sweat‐Based Tracking of L‐Dopa Pharmacokinetic Profiles Following an Oral Tablet Administration
| العنوان: | Non‐Invasive Sweat‐Based Tracking of L‐Dopa Pharmacokinetic Profiles Following an Oral Tablet Administration |
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| المؤلفون: | Hazhir Teymourian, Thitaporn Sonsa-ard, Nickey Huang, Joseph Wang, Katherine Longardner, Ernesto De la Paz, Kuldeep Mahato, Juliane R. Sempionatto, Jong-Min Moon, Irene Litvan |
| المصدر: | Angewandte Chemie, vol 133, iss 35 Angew Chem Int Ed Engl |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Levodopa, Administration, Oral, Biosensing Techniques, Pharmacology, Neurodegenerative, Catalysis, Article, SWEAT, Pharmacokinetics, Clinical Research, Medicine, Humans, Dental/Oral and Craniofacial Disease, Sweat, Parkinson's Disease, integumentary system, medicine.diagnostic_test, business.industry, Monophenol Monooxygenase, Non invasive, Disease progression, Organic Chemistry, Neurosciences, Hydrogels, General Chemistry, Plasma levels, Electrochemical Techniques, General Medicine, Enzymes, Immobilized, Brain Disorders, Therapeutic drug monitoring, Chemical Sciences, Finger touch, Drug Monitoring, business, Oxidation-Reduction, medicine.drug, Tablets |
| الوصف: | Levodopa (L-Dopa) is the ‘gold-standard’ medication for symptomatic therapy of Parkinson disease (PD). However, L-Dopa long-term use is associated with the development of motor and non-motor complications, primarily due to its fluctuating plasma levels in combination with the disease progression. Herein, we present the first example of individualized therapeutic drug monitoring for subjects upon intake of standard L-Dopa oral pill, centered on dynamic tracking of the drug concentration in naturally secreted fingertip sweat. The touch-based non-invasive detection method relies on instantaneous collection of fingertip sweat on a highly permeable hydrogel that transports the sweat to a biocatalytic tyrosinase-modified electrode, where sweat L-Dopa is measured by reduction of the dopaquinone enzymatic product. Personalized dose-response relationship is demonstrated within a group of human subjects, along with close pharmacokinetic correlation between the finger touch-based fingertip sweat and capillary blood samples. The new detection method obviates the need for frequent blood sampling and holds considerable promise for creating optimized, personalized therapeutic regimens for individuals with PD. |
| تدمد: | 1521-3757 0044-8249 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6704d3fb5d9c544caa5e6f9c327007Test https://doi.org/10.1002/ange.202106674Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7e6704d3fb5d9c544caa5e6f9c327007 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15213757 00448249 |
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