دورية أكاديمية
Consensus subtypes of hepatocellular carcinoma associated with clinical outcomes and genomic phenotypes
| العنوان: | Consensus subtypes of hepatocellular carcinoma associated with clinical outcomes and genomic phenotypes |
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| المساهمون: | Sung Hwan Lee, Sun Young Yim, Yun Seong Jeong, Qi-Xiang Li, Sang-Hee Kang, Bo Hwa Sohn, Shwetha V Kumar, Ji-Hyun Shin, You Rhee Choi, Jae-Jun Shim, Hayeon Kim, Ji Hoon Kim, Shin Kim, Sheng Guo, Randy L Johnson, Ahmed Kaseb, Koo Jeong Kang, Yun Shin Chun, Hee Jin Jang, Byoung Gill Lee, Hyun Goo Woo, Min Jin Ha, Rehan Akbani, Lewis R Roberts, David A Wheeler, Ju-Seog Lee, Ha, Min Jin |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Carcinoma, Hepatocellular* / pathology, Consensus, Female, Genomics, Humans, Liver Neoplasms* / pathology, Male, Phenotype, Proteomics, beta Catenin / genetics |
| الوصف: | Background and aims: Although many studies revealed transcriptomic subtypes of HCC, concordance of the subtypes are not fully examined. We aim to examine a consensus of transcriptomic subtypes and correlate them with clinical outcomes. Approach and results: By integrating 16 previously established genomic signatures for HCC subtypes, we identified five clinically and molecularly distinct consensus subtypes. STM (STeM) is characterized by high stem cell features, vascular invasion, and poor prognosis. CIN (Chromosomal INstability) has moderate stem cell features, but high genomic instability and low immune activity. IMH (IMmune High) is characterized by high immune activity. BCM (Beta-Catenin with high Male predominance) is characterized by prominent β-catenin activation, low miRNA expression, hypomethylation, and high sensitivity to sorafenib. DLP (Differentiated and Low Proliferation) is differentiated with high hepatocyte nuclear factor 4A activity. We also developed and validated a robust predictor of consensus subtype with 100 genes and demonstrated that five subtypes were well conserved in patient-derived xenograft models and cell lines. By analyzing serum proteomic data from the same patients, we further identified potential serum biomarkers that can stratify patients into subtypes. Conclusions: Five HCC subtypes are correlated with genomic phenotypes and clinical outcomes and highly conserved in preclinical models, providing a framework for selecting the most appropriate models for preclinical studies. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0270-9139 1527-3350 35349735 |
| العلاقة: | HEPATOLOGY; J00985; OAK-2022-08716; https://ir.ymlib.yonsei.ac.kr/handle/22282913/192359Test; T202205582; HEPATOLOGY, Vol.76(6) : 1634-1648, 2022-12 |
| DOI: | 10.1002/hep.32490 |
| الإتاحة: | https://doi.org/10.1002/hep.32490Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/192359Test |
| حقوق: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.5961756A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02709139 15273350 35349735 |
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| DOI: | 10.1002/hep.32490 |