Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria
العنوان: | Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria |
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المؤلفون: | David P. Fewer, Pavel Hrouzek, Jouni Jokela, Tomáš Galica, Reidun Aesoy, Lars Herfindal, Kaarina Sivonen, Lassi Matti Petteri Heinilä |
المساهمون: | Department of Microbiology, Department of Food and Nutrition, Helsinki Institute of Sustainability Science (HELSUS), Microbial Natural Products, Faculty of Agriculture and Forestry, Cyanobacteria research |
المصدر: | Physiologia Plantarum |
بيانات النشر: | Wiley, 2021. |
سنة النشر: | 2021 |
مصطلحات موضوعية: | MECHANISM, 0106 biological sciences, 0301 basic medicine, Cyanobacteria, Antifungal, Antifungal Agents, Physiology, medicine.drug_class, MEMBRANE PERMEABILIZATION, Peptide, Plant Science, Peptides, Cyclic, PRODUCT, 01 natural sciences, Lipopeptides, 03 medical and health sciences, chemistry.chemical_compound, LAXAPHYCIN-B, Biosynthesis, Genetics, medicine, Cytotoxicity, 2. Zero hunger, chemistry.chemical_classification, biology, Lipopeptide, PEPTIDES, Biological activity, Cell Biology, General Medicine, 11831 Plant biology, biology.organism_classification, CYCLODEXTRIN, Anti-Bacterial Agents, DIGITONIN, 030104 developmental biology, chemistry, Biochemistry, Chemical diversity, PUWAINAPHYCINS, HASSALLIDIN-A, 010606 plant biology & botany |
الوصف: | Cyanobacteria produce a variety of chemically diverse cyclic lipopeptides with potent antifungal activities. These cyclic lipopeptides have an amphipathic structure comprised of a polar peptide cycle and hydrophobic fatty acid side chain. Many have antibiotic activity against a range of human and plant fungal pathogens. This review article aims to summarize the present knowledge on the chemical diversity and cellular effects of cyanobacterial cyclic lipopeptides that display antifungal activity. Cyclic antifungal lipopeptides from cyanobacteria commonly fall into four structural classes; hassallidins, puwainaphycins, laxaphycins, and anabaenolysins. Many of these antifungal cyclic lipopeptides act through cholesterol and ergosterol-dependent disruption of membranes. In many cases, the cyclic lipopeptides also exert cytotoxicity in human cells, and a more extensive examination of their biological activity and structure–activity relationship is warranted. The hassallidin, puwainaphycin, laxaphycin, and anabaenolysin structural classes are unified through shared complex biosynthetic pathways that encode a variety of unusual lipoinitiation mechanisms and branched biosynthesis that promote their chemical diversity. However, the biosynthetic origins of some cyanobacterial cyclic lipopeptides and the mechanisms, which drive their structural diversification in general, remain poorly understood. The strong functional convergence of differently organized chemical structures suggests that the production of lipopeptide confers benefits for their producer. Whether these benefits originate from their antifungal activity or some other physiological function remains to be answered in the future. However, it is clear that cyanobacteria encode a wealth of new cyclic lipopeptides with novel biotechnological and therapeutic applications. publishedVersion |
وصف الملف: | application/pdf |
تدمد: | 1399-3054 0031-9317 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e23cba5c50afda948b7896ce3a4970Test https://doi.org/10.1111/ppl.13484Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....c6e23cba5c50afda948b7896ce3a4970 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 13993054 00319317 |
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