Randomized controlled trial of intravenous immunoglobulin versus oral prednisolone in chronic inflammatory demyelinating polyradiculoneuropathy
| العنوان: | Randomized controlled trial of intravenous immunoglobulin versus oral prednisolone in chronic inflammatory demyelinating polyradiculoneuropathy |
|---|---|
| المؤلفون: | Martin Bojar, S Bensa, A. V. Swan, Hugh J. Willison, P.A. van Doorn, Isabel Illa, Giacomo P. Comi, Marinos C. Dalakas, Richard A. C. Hughes, Peter Van den Bergh, Eduardo Nobile-Orazio |
| المصدر: | Annals of Neurology. 50:195-201 |
| بيانات النشر: | Wiley, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Randomization, medicine.drug_class, Prednisolone, Administration, Oral, law.invention, Route of administration, Double-Blind Method, Randomized controlled trial, law, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Adverse effect, business.industry, Immunoglobulins, Intravenous, Polyradiculoneuropathy, Middle Aged, Prognosis, medicine.disease, Crossover study, Surgery, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Neurology, Corticosteroid, Female, Neurology (clinical), business, medicine.drug |
| الوصف: | This multicenter, randomized, double-blind, crossover trial compared a six week course of oral prednisolone tapering from 60 mg to 10 mg daily with intravenous immunoglobulin (IVIg) 2.0 g/kg given over one to two days for treating chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Twenty-four of the thirty-two randomized patients completed both treatment periods. Both treatments produced significant improvements in the primary outcome measure, change in an 11-point disability scale two weeks after randomization. There was slightly, but not significantly, more improvement after IVIg than with prednisolone, the mean difference between the groups in change in disability grade being 0.16 (95% CI = -0.35 to 0.66). There were also slightly, but not significantly, greater improvements favoring IVIg in the secondary outcome measures: time to walk 10 meters after two weeks and improvement in disability grade after six weeks. Results may have been biased against IVIg by the eight patients who did not complete the second arm of the trial. A serious adverse event (psychosis) attributable to treatment occurred in one patient while on prednisolone and in none with IVIg. |
| تدمد: | 1531-8249 0364-5134 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8af5a73f4e5e3dd8f4481b148b364ddTest https://doi.org/10.1002/ana.1088Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f8af5a73f4e5e3dd8f4481b148b364dd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15318249 03645134 |
|---|