Bortezomib in recurrent and/or refractory multiple myeloma
| العنوان: | Bortezomib in recurrent and/or refractory multiple myeloma |
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| المؤلفون: | Gordan Srkalovic, Kenneth C. Anderson, Jessica Anderson, Bart Barlogie, James R. Berenson, Raymond Alexanian, Sundar Jagannath, Paul G. Richardson, Robert Z. Orlowski, Darrell Nix, Dixie L. Esseltine, Seema Singhal |
| المصدر: | Cancer. 103:1195-1200 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, Maximum Tolerated Dose, Population, Renal function, Kidney Function Tests, Risk Assessment, Severity of Illness Index, Gastroenterology, Drug Administration Schedule, Bortezomib, Clinical Trials, Phase II as Topic, Refractory, Recurrence, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Protease Inhibitors, Renal Insufficiency, Infusions, Intravenous, education, Survival rate, Multiple myeloma, Aged, Retrospective Studies, Aged, 80 and over, education.field_of_study, Dose-Response Relationship, Drug, business.industry, Middle Aged, Prognosis, medicine.disease, Boronic Acids, Surgery, Survival Rate, Treatment Outcome, Oncology, Drug Resistance, Neoplasm, Pyrazines, Proteasome inhibitor, Female, Multiple Myeloma, business, Kidney disease, medicine.drug |
| الوصف: | Bortezomib is a potent, reversible proteasome inhibitor that has been approved for the treatment of recurrent and/or refractory multiple myeloma, but its activity in patients with renal impairment has not been studied to date.Response rates, safety, and 20S proteasome activity were assessed in relation to baseline creatinine clearance (CrCl) among patients with recurrent and/or refractory myeloma (n = 256 patients) who were treated with bortezomib in 2 Phase II trials. Bortezomib was administered by intravenous bolus on Days 1, 4, 8, and 11 of a 21-day cycle at 2 doses, 1.0 mg/m2 (n = 28 patients) and 1.3 mg/m2 (n = 228 patients).Of 10 patients with CrClor = 30 mL/minute, 7 patients completed the protocol-specified 8 cycles of treatment; 4 patients received the 1.3 mg/m2 bortezomib dose, and 3 patients received the 1.0 mg/m2 bortezomib dose. Using the European Group for Blood and Marrow Transplantation criteria, responses were assigned by an independent committee to 3 of the 10 patients (2 partial responses and 1 minimal response), a response rate similar to that of the overall treated population. Patients with CrCl80 mL/minute (n = 105 patients), 51-80 mL/minute (n = 99 patients), andor = 50 mL/minute (n = 52 patients) had similar rates of discontinuation and similar adverse event profiles. Renal function did not appear to affect the 1-hour postdose proteasome inhibition or its recovery.Clinical experience in a limited number of patients with impaired renal function suggests that bortezomib provides clinical benefit with manageable toxicities in this high-risk population. |
| تدمد: | 1097-0142 0008-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa55d1291c504b34f8f30aeba3eef30Test https://doi.org/10.1002/cncr.20888Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....caa55d1291c504b34f8f30aeba3eef30 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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