Effect of spinal cord TRH deficiency on lower motorneuron function in the rat
| العنوان: | Effect of spinal cord TRH deficiency on lower motorneuron function in the rat |
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| المؤلفون: | Ronald M. Lechan, Theodore L. Munsat, Lester S. Adelman, John J. Kelly, Ivor M. D. Jackson, Peter van den Bergh |
| المصدر: | Muscle & Nerve. 10:397-405 |
| بيانات النشر: | Wiley, 1987. |
| سنة النشر: | 1987 |
| مصطلحات موضوعية: | Male, endocrine system, medicine.medical_specialty, Physiology, 5,7-Dihydroxytryptamine, Motor Activity, Cellular and Molecular Neuroscience, Gastrocnemius muscle, Physiology (medical), Internal medicine, medicine, Animals, Neurotoxin, Dihydroxytryptamines, Thyrotropin-Releasing Hormone, Lumbar cord, Motor Neurons, Denervation, business.industry, Muscles, Rats, Inbred Strains, Anatomy, Spinal cord, Rats, Endocrinology, medicine.anatomical_structure, Spinal Cord, Excitatory postsynaptic potential, Neurology (clinical), business, hormones, hormone substitutes, and hormone antagonists, TRH DEFICIENCY, Hormone |
| الوصف: | Thyrotropin-releasing hormone (TRH), present in high concentrations in the mammalian spinal cord, exerts excitatory effects on the alpha-motorneuron (AMN) via axodendritic contacts. We used the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) to deplete TRH from the ventral horn of the spinal cord of adults rats to determine whether the tripeptide may be trophic to the AMN. The rats were studied blindly and sequentially for 11 weeks. Motor performance remained normal by clinical and electrophysiologic assessments. AMN counts were not reduced in the lumbar cord, and gastrocnemius muscle showed no evidence of denervation in treated rats. We conclude that in the adult rat chronic ventral horn TRH deficiency does not lead to AMN degeneration and is not associated with a significant alteration of AMN function. |
| تدمد: | 1097-4598 0148-639X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1289d912927a587ca989b1d7ee82aa20Test https://doi.org/10.1002/mus.880100504Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1289d912927a587ca989b1d7ee82aa20 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974598 0148639X |
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