دورية أكاديمية
Evaluation of hepatitis B virus transmission and antiviral therapy among hepatitis B surface antigen-positive pregnant women
| العنوان: | Evaluation of hepatitis B virus transmission and antiviral therapy among hepatitis B surface antigen-positive pregnant women |
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| المؤلفون: | Koruk, Süda Tekin, Batirel, Ayşe, Köse, Şükran, Akhan, Sıla Çetin, Aygen, Bilgehan, Sırmatel, Fatma |
| المساهمون: | BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, orcid:0000-0002-2540-2060, orcid:0000-0002-7598-6578, orcid:0000-0003-0442-5981, Sırmatel, Fatma |
| بيانات النشر: | Wiley |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Antiviral Therapy, Hepatitis B, Perinatal Transmission, Pregnancy |
| الوصف: | WOS:000368020900002 ; PubMed: 26369498 ; Aim: The aim of the present study was to assess the potential risk of hepatitis B virus (HBV) vertical transmission among Turkish parturient women and to evaluate the efficacy and safety of antiviral agents. Material and Methods: Data were collected retrospectively from 114 HBV-infected pregnant women and their infants in eight health institutions in Turkey. Results: The baseline characteristics of the women were: mean age, 28.3 +/- 5.2 years; alanine aminotransferase, 57.4 +/- 139.0 U/L; aspartate aminotransferase, 56.6 +/- 150.0 U/L; and HBV DNA, 8.3 x 10(7) +/- 2.6 x 10(8) copies/mL. Family history of HBV infection was detected in 53.5% (n = 61). In total, 60 (52.6%) pregnant women received tenofovir (60.0%), lamivudine (33.3%) or telbivudine (6.7%) therapy at the median gestational age of 22.2 +/- 8.5 (1-36) weeks. All infants were vaccinated and hepatitis B immune globulin was administered, with 81 of them (71.1%) available for follow-up. After completion of HBV vaccination course, 71 (87.7%) infants had protective anti-HBs levels, three (3.7%) were hepatitis B surface antigen-positive, and seven (8.6%) were hepatitis B surface antigen-negative with nonprotective anti-HBs levels. Five of the infants had low gestational birthweight but no other birth defects were observed. Conclusion: According to our results, viral load may not be the only effecting factor for transmission of HBV to children of infected mothers. Pregnant women with high viral load should be followed-up closely during pregnancy. They should begin to take tenofovir or telbivudine, which are category B drugs for pregnancy, at the beginning of the third trimester at the latest. We need new treatment strategies; and close follow-up of mothers and children is another important issue. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1341-8076 1447-0756 |
| العلاقة: | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Journal Of Obstetrics And Gynaecology Research; https://doi.org/10.1111/jog.12821Test; https://hdl.handle.net/20.500.12491/8130Test; 41; 12; 1870; 1876 |
| DOI: | 10.1111/jog.12821 |
| الإتاحة: | https://doi.org/20.500.12491/8130Test https://doi.org/10.1111/jog.12821Test https://hdl.handle.net/20.500.12491/8130Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.BC88A5BA |
| قاعدة البيانات: | BASE |
| تدمد: | 13418076 14470756 |
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| DOI: | 10.1111/jog.12821 |