دورية أكاديمية
Reducing heart dose during left breast cancer radiotherapy: Comparison among 3 radiation techniques
| العنوان: | Reducing heart dose during left breast cancer radiotherapy: Comparison among 3 radiation techniques |
|---|---|
| المؤلفون: | D'Agostino, Giuseppe Roberto, Diletto, Barbara, Mantini, Giovanna, Nardone, Luigia, Carlo Mattiucci, Gian, Catucci, Francesco, Canna, Roberta, Martino, Antonella, Azario, Luigi, Valentini, Vincenzo |
| المساهمون: | D'Agostino, Giuseppe Roberto, Diletto, Barbara, Mantini, Giovanna, Nardone, Luigia, Mattiucci, Gian Carlo, Catucci, Francesco, Canna, Roberta, Martino, Antonella, Azario, Luigi, Valentini, Vincenzo |
| بيانات النشر: | Wichtig Publishing Srl |
| سنة النشر: | 2016 |
| المجموعة: | Università Cattolica del Sacro Cuore: PubliCatt |
| مصطلحات موضوعية: | Deep inspiration breath-hold, Early breast cancer, Heart irradiation, Heart sparing, Left breast cancer radiotherapy, Adult, Aged, Breast Neoplasm, Breath Holding, Female, Heart, Human, Inhalation, Middle Aged, Radiotherapy Dosage, Radiotherapy, Adjuvant, Conformal, Intensity-Modulated, Respiration, Medicine (all), Oncology, Cancer Research, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA |
| الوصف: | Purpose: Breast cancer survivors have a high risk of cardiac death as a consequence of heart irradiation during left breast tangential radiotherapy (RT). This study compares the cardiac dose delivered by standard 3D conformal tangential RT (CRT) to that delivered by prospective-gating RT (PGRT) or 5-field intensity-modulated RT (IMRT). Methods: Patients with early left breast cancer, referred for adjuvant RT to our institution, were enrolled in this study. For each patient, 2 simulation computed tomography scans were acquired: the first during free breathing, and the second on prospective gating during deep inspiration breath-hold. The scans were monitored by the Varian RPMTM respiratory gating system. For each patient, 3 treatment plans were performed: a 3D-CRT and an IMRT plan, each based on the free-breathing scan, and a PGRT plan, based on the deep inspiration breath-hold scan. Dose-volume histograms were compared by means of the Friedman test. Results: The median mean heart dose was 3 Gy (range 0.9-7.3 Gy) in the CRT plans, 1.9 Gy (range 0.5-3.6 Gy) in the PGRT plans, and 4.5 Gy (range 1.1-10.5 Gy) in the IMRT plans (p = 0.001). The mean heart V25 was 1.2% (range 0%-9.7%), 0% (range 0%-2.0%), and 0.2% (range 0%-7.3%) for CRT, PGRT, and IMRT plans, respectively (p<0.001). Conclusions: Prospective-gating RT to the left breast offered the best protection of heart and lung, as well as a lower irradiation of the contralateral breast, compared to CRT or IMRT. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26350194; info:eu-repo/semantics/altIdentifier/wos/WOS:000377541800013; volume:102; issue:2; firstpage:184; lastpage:189; numberofpages:6; issueyear:2016; journal:TUMORI; http://hdl.handle.net/10807/92461Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84969179704; http://www.tumorijournal.com/Attach/e24eb635-2692-4455-aba0-a39713989fe4/74b52ed2-a6f0-4917-b8df-1eb03bcdd6c2Test |
| DOI: | 10.5301/tj.5000414 |
| الإتاحة: | https://doi.org/10.5301/tj.5000414Test http://hdl.handle.net/10807/92461Test http://www.tumorijournal.com/Attach/e24eb635-2692-4455-aba0-a39713989fe4/74b52ed2-a6f0-4917-b8df-1eb03bcdd6c2Test |
| رقم الانضمام: | edsbas.AC1460 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5301/tj.5000414 |
|---|