Mechanisms of mitophagy: putting the powerhouse into the doghouse
| العنوان: | Mechanisms of mitophagy: putting the powerhouse into the doghouse |
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| المؤلفون: | Joel S. Riley, Stephen W.G. Tait |
| المصدر: | Biological Chemistry. 397:617-635 |
| بيانات النشر: | Walter de Gruyter GmbH, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Programmed cell death, Ubiquitin-Protein Ligases, Clinical Biochemistry, Autophagy, Cellular homeostasis, Nanotechnology, Mitochondrion, Biology, Biochemistry, Calcium in biology, Parkin, Mitochondria, Cell biology, 03 medical and health sciences, 030104 developmental biology, Mitophagy, Animals, Humans, Disease, Signal transduction, Protein Kinases, Molecular Biology, Signal Transduction |
| الوصف: | Since entering our cells in an endosymbiotic event one billion years ago, mitochondria have shaped roles for themselves in metabolism, inflammation, calcium storage, migration, and cell death. Given this critical role in cellular homeostasis it is essential that they function correctly. Equally critical is the ability of a cell to remove damaged or superfluous mitochondria to avoid potential deleterious effects. In this review we will discuss the various mechanisms of mitochondrial clearance, with a particular focus on Parkin/PINK1-mediated mitophagy, discuss the impact of altered mitophagy in ageing and disease, and finally consider potential therapeutic benefits of targeting mitophagy. |
| تدمد: | 1437-4315 1431-6730 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd38fd0301be841f34cff8b18d8d748Test https://doi.org/10.1515/hsz-2016-0137Test |
| رقم الانضمام: | edsair.doi.dedup.....0fd38fd0301be841f34cff8b18d8d748 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374315 14316730 |
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