Spatial organization enhances versatility and specificity in cyclic di-GMP signaling
| العنوان: | Spatial organization enhances versatility and specificity in cyclic di-GMP signaling |
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| المؤلفون: | Peter L. Graumann, Sandra Kunz |
| المصدر: | Biological Chemistry. 401:1323-1334 |
| بيانات النشر: | Walter de Gruyter GmbH, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cyclic di-GMP, biology, Caulobacter crescentus, 030106 microbiology, Clinical Biochemistry, Biofilm, Motility, biology.organism_classification, Biochemistry, Phenotype, Cell biology, Protein–protein interaction, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Second messenger system, Receptor, Cyclic GMP, Molecular Biology, Signal Transduction |
| الوصف: | The second messenger cyclic di-GMP regulates a variety of processes in bacteria, many of which are centered around the decision whether to adopt a sessile or a motile life style. Regulatory circuits include pathogenicity, biofilm formation, and motility in a wide variety of bacteria, and play a key role in cell cycle progression in Caulobacter crescentus. Interestingly, multiple, seemingly independent c-di-GMP pathways have been found in several species, where deletions of individual c-di-GMP synthetases (DGCs) or hydrolases (PDEs) have resulted in distinct phenotypes that would not be expected based on a freely diffusible second messenger. Several recent studies have shown that individual signaling nodes exist, and additionally, that protein/protein interactions between DGCs, PDEs and c-di-GMP receptors play an important role in signaling specificity. Additionally, subcellular clustering has been shown to be employed by bacteria to likely generate local signaling of second messenger, and/or to increase signaling specificity. This review highlights recent findings that reveal how bacteria employ spatial cues to increase the versatility of second messenger signaling. |
| تدمد: | 1437-4315 1431-6730 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66991867595f3840a6a6338c260ddeeTest https://doi.org/10.1515/hsz-2020-0202Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f66991867595f3840a6a6338c260ddee |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374315 14316730 |
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