Adenosine deaminase activity and zinc levels in the serum of patients with diabetes mellitus
| العنوان: | Adenosine deaminase activity and zinc levels in the serum of patients with diabetes mellitus |
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| المؤلفون: | Goncagül Haklar, Yasemin Erdogan Doventas, Macit Koldas, Göksel Bahadır, Onder Sirikci, Rana Turkal |
| المصدر: | Turkish Journal of Biochemistry. 41 |
| بيانات النشر: | Walter de Gruyter GmbH, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | medicine.medical_specialty, biology, business.industry, Biochemistry (medical), Clinical Biochemistry, chemistry.chemical_element, 030209 endocrinology & metabolism, Zinc, 030204 cardiovascular system & hematology, medicine.disease, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Adenosine deaminase, Endocrinology, chemistry, Internal medicine, Diabetes mellitus, biology.protein, Medicine, business, Molecular Biology |
| الوصف: | Objective:Adenosine deaminase (ADA) specifically catalyzes the deamination of adenosine which has been proved to play an important role in modulation of insulin action on glucose metabolism. Zinc is an essential micronutrient that is directly involved in the physiology of insulin and may be an important agent to activate the ADA. We aimed to evaluate serum ADA activity, zinc levels and the relationship between these two parameters in diabetes mellitus.Methods:We investigated serum ADA activity and zinc levels in type I (n = 100) and type II diabetes mellitus patients (n = 151).Results:ADA activities of diabetic patients were significantly elevated, whereas zinc levels were significantly lower than those of healthy controls (p < 0.001). Compared with the well-controlled diabetic patient groups (HbAConclusion:Elevated ADA activity in diabetic patients with poor glycemic control may be a useful marker for therapy modulation. |
| تدمد: | 1303-829X 0250-4685 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::524e9c45662d505cd1230bb957c1cf99Test https://doi.org/10.1515/tjb-2016-0137Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........524e9c45662d505cd1230bb957c1cf99 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1303829X 02504685 |
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