التفاصيل البيبلوغرافية
| العنوان: |
Comparison between admission natriuretic peptides, NGAL and sST2 testing for the prediction of worsening renal function in patients with acutely decompensated heart failure |
| المؤلفون: |
De Berardinis, Benedetta, Gaggin, Hanna K., Magrini, Laura, Belcher, Arianna, Zancla, Benedetta, Femia, Alexandra, Simon, Mandy, Motiwala, Shweta, Bhardwaj, Anju, Parry, Blair A., Nagurney, John T., Coudriou, Charles, Legrand, Matthieu, Sadoune, Malha, Di Somma, Salvatore, Januzzi, James L., from the Global Research on Acute C |
| المصدر: |
Clinical Chemistry and Laboratory Medicine (CCLM) ; volume 53, issue 4 ; ISSN 1437-4331 1434-6621 |
| بيانات النشر: |
Walter de Gruyter GmbH |
| سنة النشر: |
2015 |
| الوصف: |
In order to predict the occurrence of worsening renal function (WRF) and of WRF plus in-hospital death, 101 emergency department (ED) patients with acute decompensated heart failure (ADHF) were evaluated with testing for amino-terminal pro-B-type natriuretic peptide (NT-proBNP), BNP, sST2, and neutrophil gelatinase associated lipocalin (NGAL). In a prospective international study, biomarkers were collected at the time of admission; the occurrence of subsequent in hospital WRF was evaluated. In total 26% of patients developed WRF. Compared to patients without WRF, those with WRF had a longer in-hospital length of stay (LOS) (mean LOS 13.1±13.4 days vs. 4.8±3.7 days, p<0.001) and higher in-hospital mortality [6/26 (23%) vs. 2/75 (2.6%), p<0.001]. Among the biomarkers assessed, baseline NT-proBNP (4846 vs. 3024 pg/mL; p=0.04), BNP (609 vs. 435 pg/mL; p=0.05) and NGAL (234 vs. 174 pg/mL; p=0.05) were each higher in those who developed WRF. In logistic regression, the combination of elevated natriuretic peptide and NGAL were additively predictive for WRF (OR : In ED patients with ADHF, the combination of NT-proBNP or BNP plus NGAL at presentation may be useful to predict impending WRF (Clinicaltrials.gov NCT#0150153). |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.1515/cclm-2014-0191 |
| DOI: |
10.1515/cclm-2014-0191/pdf |
| الإتاحة: |
https://doi.org/10.1515/cclm-2014-0191Test |
| رقم الانضمام: |
edsbas.6BC22F67 |
| قاعدة البيانات: |
BASE |
