Synthesis of New 1-Aryl-4-(biarylmethylene)piperazine Ligands, Structurally Related to Adoprazine (SLV313)
| العنوان: | Synthesis of New 1-Aryl-4-(biarylmethylene)piperazine Ligands, Structurally Related to Adoprazine (SLV313) |
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| المؤلفون: | Nisar Ullah |
| المصدر: | Zeitschrift für Naturforschung B. 67:75-84 |
| بيانات النشر: | Walter de Gruyter GmbH, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Agonist, medicine.drug_class, Stereochemistry, Aryl, General Chemistry, Buchwald–Hartwig amination, Reductive amination, Coupling reaction, chemistry.chemical_compound, Piperazine, ADOPRAZINE, chemistry, medicine, Receptor |
| الوصف: | A series of new 1-aryl-4-(biarylmethylene)piperazines has been synthesized. These ligands are structurally related to SLV-313, a potential atypical antipsychotic having potent D2 receptor antagonist and 5-HT1A receptor agonist properties. Buchwald-Hartwig coupling reactions of 1-boc-piperazine with appropriate aryl halides and subsequent removal of the boc group rendered arylpiperazines. The reductive amination of the latter with suitable biarylaldehydes accomplished the synthesis of these ligands. |
| تدمد: | 1865-7117 0932-0776 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059b5a62066095e1d4f6595ba1bf624bTest https://doi.org/10.1515/znb-2012-0113Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....059b5a62066095e1d4f6595ba1bf624b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18657117 09320776 |
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