Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function
| العنوان: | Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function |
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| المؤلفون: | Albena T. Dinkova-Kostova, Noemí Esteras, Andrey Y. Abramov |
| المصدر: | Biological Chemistry. 397:383-400 |
| بيانات النشر: | Walter de Gruyter GmbH, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, NF-E2-Related Factor 2, Clinical Biochemistry, Biology, Mitochondrion, medicine.disease_cause, Biochemistry, Glycogen Synthase Kinase 3, 03 medical and health sciences, GSK-3, medicine, Animals, Humans, Amyotrophic lateral sclerosis, Molecular Biology, Transcription factor, Neurodegeneration, Brain, Membrane Transport Proteins, Neurodegenerative Diseases, Lipid Metabolism, medicine.disease, KEAP1, Mitochondria, Cell biology, 030104 developmental biology, DNAJA3, Energy Metabolism, Oxidative stress |
| الوصف: | The nuclear factor erythroid-derived 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor well-known for its function in controlling the basal and inducible expression of a variety of antioxidant and detoxifying enzymes. As part of its cytoprotective activity, increasing evidence supports its role in metabolism and mitochondrial bioenergetics and function. Neurodegenerative diseases are excellent candidates for Nrf2-targeted treatments. Most neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal dementia and Friedreich’s ataxia are characterized by oxidative stress, misfolded protein aggregates, and chronic inflammation, the common targets of Nrf2 therapeutic strategies. Together with them, mitochondrial dysfunction is implicated in the pathogenesis of most neurodegenerative disorders. The recently recognized ability of Nrf2 to regulate intermediary metabolism and mitochondrial function makes Nrf2 activation an attractive and comprehensive strategy for the treatment of neurodegenerative disorders. This review aims to focus on the potential therapeutic role of Nrf2 activation in neurodegeneration, with special emphasis on mitochondrial bioenergetics and function, metabolism and the role of transporters, all of which collectively contribute to the cytoprotective activity of this transcription factor. |
| تدمد: | 1437-4315 1431-6730 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b203cc5d84e06233220baa32b16a02Test https://doi.org/10.1515/hsz-2015-0295Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....82b203cc5d84e06233220baa32b16a02 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374315 14316730 |
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