Endocervical immune mediator production following successful rescue or ultrasound indicated cerclage placement
| العنوان: | Endocervical immune mediator production following successful rescue or ultrasound indicated cerclage placement |
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| المؤلفون: | Daniel W. Skupski, Tomi T. Kanninen, Steven S. Witkin, Catherine Herway, Gary S. Eglinton |
| المصدر: | Journal of Perinatal Medicine. 40 |
| بيانات النشر: | Walter de Gruyter GmbH, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, medicine.medical_treatment, HSP27 Heat-Shock Proteins, Gestational Age, Cervix Uteri, Immune system, Mediator, Pregnancy, Transforming Growth Factor beta, medicine, Humans, Cervical cerclage, Hyaluronic Acid, Cervix, Cervical length, Cerclage, Cervical, Ultrasonography, Gynecology, business.industry, Ultrasound, Obstetrics and Gynecology, Ecm degradation, Extracellular Matrix, Surgery, Matrix Metalloproteinase 8, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Basigin, Gestation, Female, Matrix Metalloproteinase 1, business, Cervical Ripening |
| الوصف: | Placement of a cervical cerclage at mid-trimester in women at risk for preterm labor is a common procedure with apparent benefits for some women. However, the changes that occur in the cervix following this procedure remain incompletely identified.We evaluated the endocervical concentrations of mediators involved in extracellular matrix (ECM) stabilization or degradation prior to, and up to 120 days following, cerclage placement in 53 women who underwent an ultrasound-indicated or a rescue cerclage at 15-25 weeks of gestation due to a cervical length1.5 cm. All delivered a healthy neonate at term. Samples were tested by enzyme-linked immunosorbent assay for concentrations of hyaluronan (HA), 27 kDa heat shock protein (hsp27), transforming growth factor-β (TGF-β), extracellular matrix metalloproteinase inducer (CD147/EMMPRIN), and matrix metalloproteinase (MMP)-1 and -8.Concentrations of both HA and hsp27 were highest at the time of cerclage placement and then decreased while TGF-β and EMMPRIN increased in concentration following the procedure. The highest mean EMMPRIN level was measured at90 days following the procedure while TGF-β levels peaked at 61-90 days post-cerclage. MMP-1 and MMP-8 were not detected over the study time period.In women with a successful cerclage placement the selective regulation of mediators inhibits progression of ECM degradation and cervical ripening. |
| تدمد: | 1619-3997 0300-5577 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9159a05245342b91d235e9bf5d08de4dTest https://doi.org/10.1515/jpm.2011.132Test |
| رقم الانضمام: | edsair.doi.dedup.....9159a05245342b91d235e9bf5d08de4d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16193997 03005577 |
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