Addressing Confounding in Predictive Models with an Application to Neuroimaging
| العنوان: | Addressing Confounding in Predictive Models with an Application to Neuroimaging |
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| المؤلفون: | Bilwaj Gaonkar, Russell T. Shinohara, Jimit Doshi, Christos Davatzikos, Kristin A. Linn |
| المصدر: | The International Journal of Biostatistics. 12:31-44 |
| بيانات النشر: | Walter de Gruyter GmbH, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Statistics and Probability, Multivariate statistics, Complex disease, Pattern analysis, Neuroimaging, computer.software_genre, 01 natural sciences, Article, Pattern Recognition, Automated, Machine Learning, 010104 statistics & probability, 03 medical and health sciences, 0302 clinical medicine, Humans, 0101 mathematics, Mathematics, Inverse probability weighting, Confounding, Brain, Probability and statistics, General Medicine, Magnetic Resonance Imaging, Pattern recognition (psychology), Data mining, Statistics, Probability and Uncertainty, human activities, computer, 030217 neurology & neurosurgery, Cognitive psychology |
| الوصف: | Understanding structural changes in the brain that are caused by a particular disease is a major goal of neuroimaging research. Multivariate pattern analysis (MVPA) comprises a collection of tools that can be used to understand complex disease efxcfects across the brain. We discuss several important issues that must be considered when analyzing data from neuroimaging studies using MVPA. In particular, we focus on the consequences of confounding by non-imaging variables such as age and sex on the results of MVPA. After reviewing current practice to address confounding in neuroimaging studies, we propose an alternative approach based on inverse probability weighting. Although the proposed method is motivated by neuroimaging applications, it is broadly applicable to many problems in machine learning and predictive modeling. We demonstrate the advantages of our approach on simulated and real data examples. |
| تدمد: | 1557-4679 2194-573X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde8a956ef7cf04746678bddefeff443Test https://doi.org/10.1515/ijb-2015-0030Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dde8a956ef7cf04746678bddefeff443 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15574679 2194573X |
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