دورية أكاديمية
Androgen receptor in triple negative breast cancer: A potential target for the targetless subtype
| العنوان: | Androgen receptor in triple negative breast cancer: A potential target for the targetless subtype |
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| المؤلفون: | Gerratana, L., Basile, D., Buono, G., De Placido, S., Giuliano, M., Minichillo, S., Coinu, A., Martorana, F., De Santo, I., Del Mastro, L., De Laurentiis, M., Puglisi, F., Arpino, G. |
| المساهمون: | Gerratana, L., Basile, D., Buono, G., De Placido, S., Giuliano, M., Minichillo, S., Coinu, A., Martorana, F., De Santo, I., Del Mastro, L., De Laurentiis, M., Puglisi, F., Arpino, G. |
| بيانات النشر: | W.B. Saunders Ltd |
| سنة النشر: | 2018 |
| المجموعة: | Università degli Studi di Genova: CINECA IRIS |
| مصطلحات موضوعية: | Antiandrogen therapy, Epithelial-to-Mesenchymal Transition, Luminal androgen receptor positive, Triple negative breast cancer, Oncology, Radiology, Nuclear Medicine and Imaging |
| الوصف: | Triple negative breast cancer (TNBC) represents the 15–20% of all breast cancers (BC) and is characterized by a very aggressive behavior. Recent data suggest that TNBC is not a single disease, but it is rather an umbrella for different ontology-profiles such as basal like 1 and 2, mesenchymal, and the luminal androgen receptor (LAR). The LAR subtype is characterized by the expression of the Androgen Receptor (AR) and its downstream effects. Notwithstanding the role of the AR in several signaling pathways, its impact on a biological and clinical standpoint is still controversial. The LAR subtype has been associated with better prognosis, less chemotherapy responsiveness and lower pathologic complete response after neoadjuvant treatment. Clinical evidence suggests a role for anti-androgen therapies such as bicalutamide, enzalutamide and abiraterone, offering an interesting chemo-free alternative for chemo-unresponsive patients, and therefore potentially shifting current treatment strategies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29940524; info:eu-repo/semantics/altIdentifier/wos/WOS:000440882400013; volume:68; firstpage:102; lastpage:110; numberofpages:9; journal:CANCER TREATMENT REVIEWS; http://hdl.handle.net/11567/914067Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85048885009 |
| DOI: | 10.1016/j.ctrv.2018.06.005 |
| الإتاحة: | https://doi.org/10.1016/j.ctrv.2018.06.005Test http://hdl.handle.net/11567/914067Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.25C8AEAF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ctrv.2018.06.005 |
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