دورية أكاديمية

Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development

التفاصيل البيبلوغرافية
العنوان: Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development
المؤلفون: Delang, Leen, Paeshuyse, Jan, Vliegen, Inge, Obeid, Susan, Leyssen, Pieter, Durantel, David, Zoulim, Fabien, Op de Beeck, Anne, Neyts, Johan
بيانات النشر: W.B. Saunders
سنة النشر: 2009
المجموعة: KU Leuven: Lirias
مصطلحات موضوعية: Antiviral Agents, Cells, Cultured, Drug Resistance, Viral, Drug Synergism, Hepacivirus, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Time Factors
الوصف: Statins are 3-hydroxyl-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors used for the treatment of hypercholesterolemia. It was recently reported that statins inhibit in vitro hepatitis C virus (HCV) RNA replication. We here report that, of five statins studied, mevastatin and simvastatin exhibit the strongest in vitro anti-HCV activity, lovastatin and fluvastatin have moderate inhibitory effects, and pravastatin is devoid of an antiviral effect. A combination of statins with interferon-alpha (IFN-alpha) or HCV nonstructural (NS)5B polymerase or NS3 protease inhibitors results in an additive antiviral activity in short-term (3 days) antiviral assays. Neither statins, at a concentration of five-fold their median effective concentration (EC(50)) value, nor polymerase, protease inhibitors, or IFN-alpha, at concentrations 10- or 20-fold their EC(50) value, were able to clear cells from their replicon following four or six consecutive passages of antiviral pressure. However, the combination of HCV polymerase or protease inhibitors with mevastatin or simvastatin resulted in an efficient clearance of the cultures from their replicon. In colony formation experiments, mevastatin reduced the frequency or prevented the selection of HCV replicons resistant to the nonnucleoside inhibitor HCV-796. Conclusion: A combination of specific HCV inhibitors with statins may result in a more profound antiviral effect and may delay or prevent the development of resistance to such inhibitors. ; status: published
نوع الوثيقة: article in journal/newspaper
وصف الملف: 1684660 bytes; application/pdf
اللغة: unknown
تدمد: 0270-9139
العلاقة: Hepatology vol:50 issue:1 pages:6-16; https://lirias.kuleuven.be/handle/123456789/203349Test; https://lirias.kuleuven.be/bitstream/123456789/203349/3//HEP-08-1447.R1_Lirias.pdfTest
الإتاحة: https://lirias.kuleuven.be/handle/123456789/203349Test
https://lirias.kuleuven.be/bitstream/123456789/203349/3//HEP-08-1447.R1_Lirias.pdfTest
رقم الانضمام: edsbas.8BE4080A
قاعدة البيانات: BASE