التفاصيل البيبلوغرافية
| العنوان: |
Six-Month Survival After Extracorporeal Membrane Oxygenation for Severe COVID-19 |
| المؤلفون: |
Biancari, Fausto, Mariscalco, Giovanni, Dalen, Magnus, Settembre, Nicla, Welp, Henryk, Perrotti, Andrea, Wiebe, Karsten, Leo, Enrico, Loforte, Antonio, Chocron, Sidney, Pacini, Davide, Juvonen, Tatu, Broman, L. Mikael, Di Perna, Dario, Yusuff, Hakeem, Harvey, Chris, Mongardon, Nicolas, Maureira, Juan P., Levy, Bruno, Falk, Lars, Ruggieri, Vito G., Zipfel, Svante, Folliguet, Thierry, Fiore, Antonio |
| المساهمون: |
HUS Heart and Lung Center, III kirurgian klinikka, Department of Surgery, Clinicum |
| بيانات النشر: |
W B SAUNDERS CO-ELSEVIER INC |
| سنة النشر: |
2021 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
extracorporeal membrane oxygenation, ECMO, ECLS, coronavirus disease 2019, COVID-19, acute respiratory distress syndrome, ARDS, RESPIRATORY-DISTRESS-SYNDROME, OUTCOMES, SUPPORT, COHORT, 3126 Surgery, anesthesiology, intensive care, radiology |
| الوصف: |
Objectives: The authors evaluated the outcome of adult patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) requiring the use of extracorporeal membrane oxygenation (ECMO). Design: Multicenter retrospective, observational study. Setting: Ten tertiary referral university and community hospitals. Participants: Patients with confirmed severe COVID-19-related ARDS. Interventions: Venovenous or venoarterial ECMO. Measurements and Main Results: One hundred thirty-two patients (mean age 51.1 +/- 9.7 years, female 17.4%) were treated with ECMO for confirmed severe COVID-19-related ARDS. Before ECMO, the mean Sequential Organ Failure Assessment score was 10.1 +/- 4.4, mean pH was 7.23 +/- 0.09, and mean PaO2/fraction of inspired oxygen ratio was 77 +/- 50 mmHg. Venovenous ECMO was adopted in 122 patients (92.4%) and venoarterial ECMO in ten patients (7.6%) (mean duration, 14.6 +/- 11.0 days). Sixty-three (47.7%) patients died on ECMO and 70 (53.0%) during the index hospitalization. Six-month all-cause mortality was 53.0%. Advanced age (per year, hazard ratio [HR] 1.026, 95% CI 1.000-1-052) and low arterial pH (per unit, HR 0.006, 95% CI 0.000-0.083) before ECMO were the only baseline variables associated with increased risk of six-month mortality. Conclusions: The present findings suggested that about half of adult patients with severe COVID-19 -related ARDS can be managed successfully with ECMO with sustained results at six months. Decreased arterial pH before ECMO was associated significantly with early mortality. Therefore, the authors hypothesized that initiation of ECMO therapy before severe metabolic derangements subset may improve survival rates significantly in these patients. These results should be viewed in the light of a strict patient selection policy and may not be replicated in patients with advanced age or multiple comorbidities. (C) 2021 The Authors. Published by Elsevier Inc. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
M.D. was financially supported by a research grant from The Swedish Heart-Lung Foundation (grant number 20200412).; Biancari , F , Mariscalco , G , Dalen , M , Settembre , N , Welp , H , Perrotti , A , Wiebe , K , Leo , E , Loforte , A , Chocron , S , Pacini , D , Juvonen , T , Broman , L M , Di Perna , D , Yusuff , H , Harvey , C , Mongardon , N , Maureira , J P , Levy , B , Falk , L , Ruggieri , V G , Zipfel , S , Folliguet , T & Fiore , A 2021 , ' Six-Month Survival After Extracorporeal Membrane Oxygenation for Severe COVID-19 ' , Journal of Cardiothoracic and Vascular Anesthesia , vol. 35 , no. 7 , pp. 1999-2006 . https://doi.org/10.1053/j.jvca.2021.01.027Test; 0d0e2e58-10f7-4524-af86-3266bdea4217; http://hdl.handle.net/10138/333352Test; 000655505900013 |
| الإتاحة: |
http://hdl.handle.net/10138/333352Test |
| حقوق: |
cc_by_nc_nd ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.2856210D |
| قاعدة البيانات: |
BASE |
