دورية أكاديمية
An Italian consensus on the management of Lennox-Gastaut syndrome
| العنوان: | An Italian consensus on the management of Lennox-Gastaut syndrome |
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| المؤلفون: | Riva, Antonella, Coppola, Antonietta, Bonaventura, Carlo Di, Elia, Maurizio, Ferlazzo, Edoardo, Gobbi, Giuseppe, Marini, Carla, Meletti, Stefano, Romeo, Antonino, Santoro, Katia, Verrotti, Alberto, Capovilla, Giuseppe, Striano, Pasquale, Collaborators Italian LGS Delphi Group: Umberto Aguglia, Irene Bagnasco, Emanuele Bartolini, Domenica Battaglia, Francesca Beccaria, Vincenzo Belcastro, Pia Bernardo, Paolo Bonanni, Clementina Boniver, Alice Bonuccelli, Eleonora Briatore, Francesco Brigo, Elisabetta Cesaroni, Roberta Coa, Cinzia Costa, Alfredo D'Aniello, Valentina De Giorgis, Giancarlo Di Gennaro, Anna Rita Ferrari, Francesca Marchese, Sara Matricardi, Tullio Messana, Alessandra Morano, Francesca Felicia Operto, Alessandro Orsini, Lucio Parmeggiani, Cinzia Peruzzi, Dario Pruna, Monica Puligheddu, Patrizia Pulitano, Francesca Ragona, Andrea Romigi, Anna Rosati, Eleonora Rosati, Angelo Russo, Stefano Sartori, Carlotta Spagnoli, Maria Spanò, Antonio Trabacca, Serena Troisi, Maurizio Viri, Claudio Zucca |
| المساهمون: | Antonella, Riva, Antonietta, Coppola, Carlo Di, Bonaventura, Maurizio, Elia, Edoardo, Ferlazzo, Giuseppe, Gobbi, Carla, Marini, Stefano, Meletti, Antonino, Romeo, Katia, Santoro, Alberto, Verrotti, Giuseppe, Capovilla, Pasquale, Striano, Italian LGS Delphi Group: Umberto Aguglia, Collaborator, Bagnasco, Irene, Bartolini, Emanuele, Battaglia, Domenica, Beccaria, Francesca, Belcastro, Vincenzo, Bernardo, Pia, Bonanni, Paolo, Boniver, Clementina, Bonuccelli, Alice, Briatore, Eleonora, Brigo, Francesco, Cesaroni, Elisabetta, Coa, Roberta, Costa, Cinzia, D'Aniello, Alfredo, De Giorgis, Valentina, Di Gennaro, Giancarlo, Rita Ferrari, Anna, Marchese, Francesca, Matricardi, Sara, Messana, Tullio, Morano, Alessandra, Felicia Operto, Francesca, Orsini, Alessandro, Parmeggiani, Lucio, Peruzzi, Cinzia, Pruna, Dario, Puligheddu, Monica, Pulitano, Patrizia, Ragona, Francesca, Romigi, Andrea, Rosati, Anna, Rosati, Eleonora, Russo, Angelo, Sartori, Stefano, Spagnoli, Carlotta, Spanò, Maria, Trabacca, Antonio, Troisi, Serena, Viri, Maurizio, Zucca, Claudio |
| بيانات النشر: | W B SAUNDERS CO LTD |
| سنة النشر: | 2022 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Antiseizure medication, Consensu, Lennox-Gastaut syndrome, Pediatric epilepsy |
| الوصف: | Purpose: Although international guidelines exist, the clinical heterogeneity of Lennox-Gastaut syndrome (LGS) and the increasing availability of new and repurposed drugs (e.g., fenfluramine and cannabidiol) requires a practical guide to patient management in the clinical context. We report the results of a consensus survey among 42 Italian experts in the diagnosis and treatment of LGS. Methods: The consensus procedure followed a modified Delphi approach. Statements were formulated, based on the most recent published evidence and the clinicians' personal experience, then discussed, and agreed upon by the experts through a two-round voting procedure. Approval of a statement was reached with an average score >= 7. Results: Thirteen statements dealing with three main topics (i.e., clinical diagnosis and prognosis, impact on the Quality of Life (QoL), and treatment strategies) were generated. Six statements achieved a level of agreement sufficient for approval on the first voting round. Following the discussion and a few consequent amendments, most of the statements increased their level of agreement and all 13 were approved. Conclusions: Overall, the statements draw a slightly more benign picture of this rare and severe disease, highlighting the possibility of remission - albeit modest -, an apparent trend towards lower mortality, and the availability of several effective drugs, to which greater accessibility would be hoped for. Valproate remains a major therapeutic option in LGS patients although lamotrigine, rufinamide, topiramate, cannabidiol, and clobazam are popular therapeutic options in Italy, allowing for a tailor-made antiseizure therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35981474; info:eu-repo/semantics/altIdentifier/wos/WOS:000862844300010; volume:101; firstpage:134; lastpage:140; numberofpages:7; journal:SEIZURE; https://hdl.handle.net/11577/3464543Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85136099637 |
| DOI: | 10.1016/j.seizure.2022.07.004 |
| الإتاحة: | https://doi.org/10.1016/j.seizure.2022.07.004Test https://hdl.handle.net/11577/3464543Test |
| رقم الانضمام: | edsbas.630ECF0B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.seizure.2022.07.004 |
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