التفاصيل البيبلوغرافية
| العنوان: |
Catheter directed thrombolytic therapy and aspiration thrombectomy in intermediate pulmonary embolism with long term results |
| المؤلفون: |
Ruzsa, Zoltan, Vámosi, Zoltan, Berta, Balázs, Nemes, Balázs, Tóth, Károly, Kovács, Nándor, Zima, Endre, Becker, Dávid, Merkely, Béla |
| المصدر: |
Cardiology Journal; Vol 27, No 4 (2020); 368-375 |
| بيانات النشر: |
Via Medica |
| سنة النشر: |
2020 |
| المجموعة: |
Via Medica Journals |
| مصطلحات موضوعية: |
pulmonary embolism, local thrombolysis |
| الوصف: |
Background: Catheter directed thrombolysis (CDT) and thrombectomy represent well established techniques for the treatment of intermediate pulmonary embolism (IPE). The long-term effect of catheterdirected thrombolysis of IPE is unknown.Methods: Clinical, interventional and echocardiographic data from 80 consecutive patients with IPE who were treated with CDT were evaluated. Primary end-points were technical success and major adverse events. Secondary end-points were cardiovascular mortality, all-cause mortality, clinical success, rate of bleeding complications, improvement in pulmonary pressure and echocardiography parameters. CDT completed with alteplase (10 mg bolus and 1 mg/h maintenance dose) through a pig-tail catheter for 24 h. After 24 h, control pulmonary angiography was performed. Results: In total, 80 patients with a mean age of 59.0 ± 16.8 years were treated. CDT was successful after the first post-operative day in 72 (90%) patients, but thrombus aspiration and fragmentation was performed due to failed thrombolysis in 8 (10%) patients. Final technical and clinical success was reached in 79 (98.8%) and 77 (96.3%) patients, respectively. The mean CDT time in IPE was 27.8 ± 9.6 h. Invasive pulmonary pressure dropped from 57.5 ± 16.7 to 38.9 ± 13.5 (p < 0.001). A caval filter was implanted in 4 (5%) patients. The 1-year major adverse events and cardiovascular mortality rate was 4.0% and 1.4%, respectively. Access site complications (6 major and 6 minor) were encountered in 12 (16.2%) patients.Conclusions: Catheter directed thrombolysis in submassive pulmonary embolism had excellent results. However, additional mechanical thrombectomy was necessary in some patients to achieve good clinical outcomes. |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://journals.viamedica.pl/cardiology_journal/article/view/CJ.a2020.0060Test |
| DOI: |
10.5603/CJ.a2020.0060 |
| الإتاحة: |
https://doi.org/10.5603/CJ.a2020.0060Test
https://journals.viamedica.pl/cardiology_journal/article/view/CJ.a2020.0060Test |
| حقوق: |
Completion of the online submission form electronically is tantamount to automatically and free-of-charge transferring of the copyright for publishing and distribution of the submitted material (in all known now and developed in the future forms and fields of exploitation) to the Publisher, under condition that those materials are accepted for publication. The authors agree not to publish any data or figures presented in their work anywhere and in any language without the prior written consent of the owner of the copyrights, i.e. the Publisher. |
| رقم الانضمام: |
edsbas.45BFE4CE |
| قاعدة البيانات: |
BASE |
