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Increased HSF1 expression predicts shorter disease-specific survival of prostate cancer patients following radical prostatectomy

التفاصيل البيبلوغرافية
العنوان: Increased HSF1 expression predicts shorter disease-specific survival of prostate cancer patients following radical prostatectomy
المؤلفون: Lea Sistonen, Anna Bützow, Malin Åkerfelt, Johanna K. Björk, Johan Lundin, Andrew Erickson, Tuomas Mirtti, Antti Rannikko, Ilmari Ahonen, Stig Nordling, Mikael Lundin, Matthias Nees
المساهمون: biolääketieteen laitos, yhteiset, Institute of Biomedicine, tilastotiede, Statistics, 2606103, 2607100
بيانات النشر: Impact Journals LLC
Yhdysvallat (USA)
United States
US
سنة النشر: 2022
المجموعة: University of Turku: UTUPub / Turun yliopisto
الوصف: Prostate cancer is a highly heterogeneous disease and the clinical outcome is varying. While current prognostic tools are regarded insufficient, there is a critical need for markers that would aid prognostication and patient risk-stratification. Heat shock transcription factor 1 (HSF1) is crucial for cellular homeostasis, but also a driver of oncogenesis. The clinical relevance of HSF1 in prostate cancer is, however, unknown. Here, we identified HSF1 as a potential biomarker in mRNA expression datasets on prostate cancer. Clinical validation was performed on tissue microarrays from independent cohorts: one constructed from radical prostatectomies from 478 patients with long term follow-up, and another comprising of regionally advanced to distant metastatic samples. Associations with clinical variables and disease outcomes were investigated. Increased nuclear HSF1 expression correlated with disease advancement and aggressiveness and was, independently from established clinicopathological variables, predictive of both early initiation of secondary therapy and poor disease-specific survival. In a joint model with the clinical Cancer of the Prostate Risk Assessment post-Surgical (CAPRA-S) score, nuclear HSF1 remained a predictive factor of shortened disease-specific survival. The results suggest that nuclear HSF1 expression could serve as a novel prognostic marker for patient risk-stratification on disease progression and survival after radical prostatectomy.
نوع الوثيقة: other/unknown material
اللغة: English
تدمد: 1949-2553
العلاقة: Oncotarget; 58; https://www.utupub.fi/handle/10024/170318Test; URN:NBN:fi-fe2021042719676
الإتاحة: https://www.utupub.fi/handle/10024/170318Test
رقم الانضمام: edsbas.2EE5DA15
قاعدة البيانات: BASE
الوصف
تدمد:19492553