Significance of decoy receptor 3 in sera of hepatocellular carcinoma patients
| العنوان: | Significance of decoy receptor 3 in sera of hepatocellular carcinoma patients |
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| المؤلفون: | Gang Chen, Meisongzhu Yang, Yi-Wu Dang, Dian-Zhong Luo |
| المصدر: | Upsala Journal of Medical Sciences |
| بيانات النشر: | Uppsala Medical Society, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Carcinoma, Hepatocellular, Cirrhosis, Enzyme-Linked Immunosorbent Assay, Metastasis, hepatocellular carcinoma (HCC), Recurrence, Biomarkers, Tumor, Cholecystitis, medicine, Carcinoma, Humans, Clinical significance, enzyme-linked immunosorbent assay (ELISA), Neoplasm Metastasis, Receptor, Aged, business.industry, Liver Neoplasms, Receptors, Tumor Necrosis Factor, Member 6b, General Medicine, Middle Aged, medicine.disease, digestive system diseases, immunohistochemistry (IHC), Gene Expression Regulation, Neoplastic, Decoy receptor 3 (DcR3), Hepatocellular carcinoma, Immunohistochemistry, Female, Original Article, Decoy receptor 3, business |
| الوصف: | Objective Decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor superfamily, is amplified and over-expressed in various cancers. The objective of the present study was to investigate the concentration of DcR3 in sera of hepatocellular carcinoma (HCC) patients and its clinical significance. Methods Serum concentrations of DcR3 were measured by enzyme-linked immunosorbent assay (ELISA) in 67 patients with HCC, 8 with liver cirrhosis, 17 with cholecystitis, and in 28 healthy individuals. Immunohistochemistry was employed to access protein expression of DcR3 in the corresponding HCC tissues. Results Serum concentrations of DcR3 in patients with HCC or cirrhosis were significantly higher than in healthy individuals (P < 0.01). Moreover, serum concentrations of DcR3 in HCC patients were associated with TNM stage, para-cirrhosis, capsular infiltration, and metastasis or recurrence of disease (P < 0.05). There was a positive correlation between the serum concentration of DcR3 and protein expression in HCC tissues (r = 0.472, P < 0.01). Conclusions The high serum concentration of DcR3 might play a certain role in pathogenesis, progress, and metastasis of HCC. Moreover, DcR3 might serve as a valuable molecular indicator in early diagnosis and contribute to predicting the clinical outcome in HCC patients. |
| تدمد: | 2000-1967 0300-9734 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8cee656d2436fc376403bc8fdb42d8eTest https://doi.org/10.3109/03009734.2010.516410Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f8cee656d2436fc376403bc8fdb42d8e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20001967 03009734 |
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