رسالة جامعية
Ο ΡΟΛΟΣ ΤΩΝ ΚΥΤΤΑΡΟΚΙΝΩΝ ΣΤΗ ΠΡΟΓΝΩΣΗ, ΠΟΡΕΙΑ ΚΑΙ ΠΑΘΟΓΕΝΕΙΑ ΤΟΥ ΠΟΛΛΑΠΛΟΥ ΜΥΕΛΩΜΑΤΟΣ ; CYTOKINES IN PROGNOSIS, COURSE AND PATHOGENESIS OF MULTIPLE MYELOMA
| العنوان: | Ο ΡΟΛΟΣ ΤΩΝ ΚΥΤΤΑΡΟΚΙΝΩΝ ΣΤΗ ΠΡΟΓΝΩΣΗ, ΠΟΡΕΙΑ ΚΑΙ ΠΑΘΟΓΕΝΕΙΑ ΤΟΥ ΠΟΛΛΑΠΛΟΥ ΜΥΕΛΩΜΑΤΟΣ ; CYTOKINES IN PROGNOSIS, COURSE AND PATHOGENESIS OF MULTIPLE MYELOMA |
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| المؤلفون: | Kyrtsonis, Maria-Cristine, Κυρτσώνη, Μαρία-Χριστίνα |
| بيانات النشر: | University of Patras Πανεπιστήμιο Πατρών |
| سنة النشر: | 1996 |
| المجموعة: | National Archive of PhD Theses (National Documentation Centre Greece) |
| مصطلحات موضوعية: | ΔΙΑΛΥΤΟΣ ΥΠΟΔΟΧΕΑΣ ΤΗΣ ΙΝΤΕΡΛΕΥΚΙΝΗΣ-6, ΙΝΤΕΡΛΕΥΚΙΝΗ-1Β ΚΑΙ ΠΑΡΑΓΟΝΤΑΣ ΝΕΚΡΩΣΗΣ ΤΟΥ ΟΓΚΟΥ-Α, Ιντερλευκίνη-4, Ιντερλευκίνη-6, Κυτταροκίνες, Παθογένεια, Πολλαπλούν μυέλωμα, Πρόγνωση, Cytokines, INTERLEUKIN-1Β AND TUMOR NECROSISFACTOR-Α, Interleukin-4, Interleukin-6, Multiple myeloma, Pathogenesis, Prognosis, SOLUBLE INTERLEUKIN-6 RECEPTOR, Ιατρική και Επιστήμες Υγείας, Κλινική Ιατρική, Medical and Health Sciences, Clinical Medicine |
| الوصف: | IT WAS THE PURPOSE OF THIS STUDY TO DETERMINE IN PATIENTS WITH MM THE SERUM LEVELS OF IL-6,SIL-6R,IL-4,IL-1Β AND TNFΑ AT DIAGNOSIS AND DURING THE COURSE OF THE DISEASE AND TO SEEK A CORRELATION WITH DISEASE ACTIVITY AND PROGNOSIS. EIGHTY MM PATIENTS, 7 PATIENTS WITH SOLITARY PLASMACYTOMA OF BONE AND 25 NORMAL CONTROLS (NC) WERE STUDIED. OF MM PATIENTS 59 RESPONDED TO TREATMENT AND 21 WERE RESISTANT. CYTOKINE SERUM LEVELS WERE MEASURED BY ELIZA. AT DIAGNOSIS, IL-6 LEVELS WERE INCREASED IN 66% OF THE PATIENTS. IN RESPONDING PATIENTS IL-6 LEVELS DECREASED IN REMISSION AND INCREASED DURING RELAPSES. IN CHEMOTHERAPY RESISTANT PATIENTS IL-6 VALUES REMAINED STABLE DURING THE COURSE OF THE DISEASE. IL-6 SERUM VALUES WERE HIGHER WHEN Β2M > 4MG/ML, CRP>8.5MG/L AND IN PATIENTS WITH ADVANCED BONE DISEASE. IN MOST PATIENTS WITH PLASMACYTOMA, SERUM IL-6 WAS INCREASED AT DIAGNOSIS AND DECREASED AFTER RADIOTHERAPY. SERUM SIL-6R LEVELS WERE HIGHER IN MM PATIENTS THAN IN NC. AT THE TIME OF DIAGNOSIS, MEDIAN SIL-6R LEVEL IN RESPONDING PATIENTS WAS 36NG/ML WHILE IN NON-RESPONDING PATIENTS 82NG/ML. PATIENTS WITH SERUM SIL-6R < 40NG/ML HAD A BETTER SURVIVAL THAN THOSE WITH SIL-6R > 40NG/ML. DURING THE COURSE OF THE DISEASE, SIL-6R LEVELS REMAINED STABLE IN MOST PATIENTS. SERUM IL-4 LEVELS AT DIAGNOSIS WERE LOWER INRESPONDING PATIENTS THAN IN NC. IN RESPONDING PATIENTS IL-4 SERUM LEVELS INCREASED DURING REMISSION IN CONTRAST WITH IL-6 LEVELS. IN NON-RESPONDING PATIENTS IL-4 LEVELS REMAINED STABLE DURING THE COURSE OF THE DISEASE. (ABSTRACT TRUNCATED) ; ΣΚΟΠΟΣ ΤΗΣ ΜΕΛΕΤΗΣ ΗΤΑΝ ΝΑ ΠΡΟΣΔΙΟΡΙΣΤΟΥΝ ΤΑ ΕΠΙΠΕΔΑ IL-6,SIL-6R,IL-4,IL-1Β ΚΑΙTNFΑ ΣΤΟΝ ΟΡΟ ΑΣΘΕΝΩΝ ΜΕ ΠΛΑΣΜΑΤΟΚΥΤΤΑΡΙΚΕΣ ΔΥΣΚΡΑΣΙΕΣ ΚΑΙ ΝΑ ΑΞΙΟΛΟΓΗΘΕΙ Η ΣΧΕΣΗ ΤΩΝ ΕΠΙΠΕΔΩΝ ΤΟΥΣ ΜΕ ΤΗ ΔΡΑΣΤΗΡΙΟΤΗΤΑ ΤΗΣ ΝΟΣΟΥ ΚΑΙ ΤΗΝ ΠΡΟΓΝΩΣΗ ΤΗΣ. ΜΕΛΕΤΗΘΗΚΑΝ 80 ΑΣΘΕΝΕΙΣ ΜΕ ΠΜ, 7 ΑΣΘΕΝΕΙΣ ΜΕ ΜΟΝΗΡΕΣ ΠΛΑΣΜΑΤΟΚΥΤΤΩΜΑ ΤΩΝ ΟΣΤΩΝΚΑΙ 25 ΦΥΣΙΟΛΟΓΙΚΟΙ ΜΑΡΤΥΡΕΣ (ΦΜ). ΑΠΟ ΤΟΥΣ ΑΣΘΕΝΕΙΣ ΜΕ ΠΜ, 59 ΑΝΤΑΠΟΚΡΙΘΗΚΑΝ ΣΤΗΝ ΑΡΧΙΚΗ ΘΕΡΑΠΕΙΑ ΕΝΩ 21 ΗΤΑΝ ΑΝΘΕΚΤΙΚΟΙ. ΤΑ ΕΠΙΠΕΔΑ ΤΩΝ ΚΥΤΤΑΡΟΚΙΝΩΝ ΠΡΟΣΔΙΟΡΙΣΘΗΚΑΝ ΜΕ ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| اللغة: | Greek, Modern (1453-) |
| العلاقة: | http://hdl.handle.net/10442/hedi/6611Test |
| DOI: | 10.12681/eadd/6611 |
| الإتاحة: | https://doi.org/10.12681/eadd/6611Test http://hdl.handle.net/10442/hedi/6611Test |
| رقم الانضمام: | edsbas.91E3B6E7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.12681/eadd/6611 |
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