رسالة جامعية
The mechanism for paraquat toxicity involves oxidative stress and inflammation : a model for Parkinson's disease
| العنوان: | The mechanism for paraquat toxicity involves oxidative stress and inflammation : a model for Parkinson's disease |
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| المؤلفون: | Miller, Rebecca Louise, 1974- |
| المساهمون: | Sun, Albert Y. |
| بيانات النشر: | University of Missouri--Columbia |
| سنة النشر: | 2007 |
| المجموعة: | University of Missouri: MOspace |
| مصطلحات موضوعية: | Reactive Oxygen Species -- metabolism, Parkinson Disease -- etiology, NADPH Oxidase -- drug effects, Nerve Degeneration -- chemically induced, Microglia -- drug effects, Paraquat -- toxicity |
| الوصف: | "May 2007" ; The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. ; Vita. ; Thesis (Ph. D.) University of Missouri-Columbia 2007. ; Parkinson's disease (PD) is a neurodegenerative disorder known to affect the dopaminergic neurons in the substantia nigra. Epidemiological studies have shown an increased risk of developing PD with exposure to paraquat. In this study, we examined the source of reactive oxygen species (ROS) and the underlying signaling pathway for paraquat-induced cytotoxicity to BV-2 microglial cells. Paraquat-induced ROS production was attenuate by inhibitors for NADPH oxidase, protein kinase C and extracellular signal-regulated kinases 1/2. Under inflammatory conditions, microglial cells respond to cytokines by induction of inducible nitric oxide synthase which produces nitric oxide (NO). Our results show that paraquat inhibited cytokine-induced NO production but only moderately enhanced ROS production in microglial cells. We wanted to determine the role of NADPH oxidase in neuronal cells. Paraquat induced the upregulation of the p67phox subunit protein and NOX2 mRNA of NADPH oxidase in differentiated SH-SY5Y cells. In conclusion, our data suggest that NADPH oxidase plays a significant role in the toxicity of paraquat. ; Includes bibliographical references. |
| نوع الوثيقة: | thesis |
| اللغة: | English |
| العلاقة: | University of Missouri--Columbia. Graduate School. Theses and Dissertations; https://doi.org/10.32469/10355/4764Test; https://hdl.handle.net/10355/4764Test; b6666200x; 316508115 |
| DOI: | 10.32469/10355/4764 |
| الإتاحة: | https://doi.org/10.32469/10355/4764Test https://hdl.handle.net/10355/4764Test |
| حقوق: | OpenAccess. ; This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. |
| رقم الانضمام: | edsbas.A6E93C20 |
| قاعدة البيانات: | BASE |
| DOI: | 10.32469/10355/4764 |
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