دورية أكاديمية
Evaluation de la thymopoiese: applications cliniques. ; Evaluation of thymopoiesis: clinical applications]
| العنوان: | Evaluation de la thymopoiese: applications cliniques. ; Evaluation of thymopoiesis: clinical applications] |
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| المؤلفون: | Castermans, Emilie, Morrhaye, Gabriel, Marchand, S., Martens, Henri, Moutschen, Michel, Geenen, Vincent, Beguin, Yves, Baron, Frédéric |
| المصدر: | Revue Médicale de Liège, 62 (12), 725-9 (2007) |
| بيانات النشر: | Université de Liège. Revue Médicale de Liège |
| سنة النشر: | 2007 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Adolescent, Adult, Aged, 80 and over, Aging/immunology, Cell Differentiation/immunology, Child, Gene Rearrangement, T-Lymphocyte/genetics, Graft vs Host Disease/immunology, Hematopoietic Stem Cell Transplantation, Homeostasis/immunology, Humans, Immunologic Memory/immunology, Lymphopoiesis/immunology, Middle Aged, Neurosecretory Systems/immunology, Receptors, Antigen, T-Cell/genetics, Recombination, Genetic/genetics, T-Lymphocytes/immunology, Thymus Gland/immunology, Transplantation Immunology/immunology, Human health sciences, Hematology, Sciences de la santé humaine, Hématologie |
| الوصف: | peer reviewed ; In the precedent article, we have described how T-cell generation in the thymus (thymopoiesis) may be currently evaluated through quantification by PCR of T-cell receptor excision circles (TREC) generated by intrathymic random recombination of the gene segments coding for variable parts of T-cell receptor for antigen (TCR). In hematology, TREC methodology helps in a better understanding of immune reconstitution after graft of hematopoietic stem cells: first there is a proliferation of mature T cells present in the graft, then a differentiation of naive T cells. In geriatrics, the homeostasis of the peripheral T-cell repertoire is maintained through proliferation of peripheral memory T cells rather than through thymic generation of naive T cells. In addition, TREC quantification constitutes a novel major tool for deciphering the tight control of thymopoiesis by the neuroendocrine system. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | French |
| تدمد: | 0370-629X 2566-1566 |
| العلاقة: | urn:issn:0370-629X; urn:issn:2566-1566; https://orbi.uliege.be/handle/2268/6982Test; info:hdl:2268/6982; https://orbi.uliege.be/bitstream/2268/6982/1/232.pdfTest; scopus-id:2-s2.0-40349086892; info:pmid:18286949 |
| الإتاحة: | https://orbi.uliege.be/handle/2268/6982Test https://orbi.uliege.be/bitstream/2268/6982/1/232.pdfTest |
| حقوق: | open access ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.55D2EFB9 |
| قاعدة البيانات: | BASE |
| تدمد: | 0370629X 25661566 |
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