دورية أكاديمية
Targeted ablation of primary cilia in differentiated dopaminergic neurons reduces striatal dopamine and responsiveness to metabolic stress
| العنوان: | Targeted ablation of primary cilia in differentiated dopaminergic neurons reduces striatal dopamine and responsiveness to metabolic stress |
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| المؤلفون: | Mustafa, Rasem, Rawas, Chahinaz, Mannal, Nadja, Kreiner, Grzegorz, Spittau, Björn, Kamińska, Katarzyna, Yilmaz, Rüstem, Pötschke, Christina, Kirsch, Joachim, Liss, Birgit, Tucker, Kerry L., Parlato, Rosanna |
| بيانات النشر: | Universität Ulm |
| سنة النشر: | 2022 |
| المجموعة: | OPARU (OPen Access Repository of Ulm University) |
| مصطلحات موضوعية: | primary cilium, intraflagellary protein, striatum, pacemaker, multielecotrode arrays (MEA), D2-autoreceptor, DDC 540 / Chemistry & allied sciences, DDC 570 / Life sciences, DDC 600 / Technology (Applied sciences), Substantia nigra, Dopamine, Autoreceptors, Corpus striatum, Dopamin, Schrittmacher |
| الوصف: | Primary cilia (PC) are microtubule-based protrusions of the cell membrane transducing molecular signals during brain development. Here, we report that PC are required for maintenance of Substantia nigra (SN) dopaminergic (DA) neurons highly vulnerable in Parkinson’s disease (PD). Targeted blockage of ciliogenesis in differentiated DA neurons impaired striato-nigral integrity in adult mice. The relative number of SN DA neurons displaying a typical auto-inhibition of spontaneous activity in response to dopamine was elevated under control metabolic conditions, but not under metabolic stress. Strikingly, in the absence of PC, the remaining SN DA neurons were less vulnerable to the PD neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP). Our data indicate conserved PC-dependent neuroadaptive responses to DA lesions in the striatum. Moreover, PC control the integrity and dopamine response of a subtype of SN DA neurons. These results reinforce the critical role of PC as sensors of metabolic stress in PD and other disorders of the dopamine system. ; publishedVersion |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://www.mdpi.com/article/10.3390/antiox10081284/s1Test; http://dx.doi.org/10.18725/OPARU-46460Test; https://oparu.uni-ulm.de/xmlui/123456789/46536Test; http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-46536-3Test |
| DOI: | 10.18725/OPARU-46460 |
| الإتاحة: | https://doi.org/10.18725/OPARU-46460Test https://oparu.uni-ulm.de/xmlui/123456789/46536Test http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-46536-3Test |
| حقوق: | CC BY 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.20B998CD |
| قاعدة البيانات: | BASE |
| DOI: | 10.18725/OPARU-46460 |
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