Exploitation vs. exploration—computational temporal and semantic analysis explains semantic verbal fluency impairment in Alzheimer's disease
| العنوان: | Exploitation vs. exploration—computational temporal and semantic analysis explains semantic verbal fluency impairment in Alzheimer's disease |
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| المؤلفون: | Jan Alexandersson, Johannes Tröger, Jutta Kray, Philippe Robert, Alexandra König, Nicklas Linz, Jessica Peter |
| المساهمون: | Deutsches Forschungszentrum für Künstliche Intelligenz GmbH = German Research Center for Artificial Intelligence (DFKI), Cognition Behaviour Technology (CobTek), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice), Spatio-Temporal Activity Recognition Systems (STARS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Psychiatric University Clinic [Bern] (UPD), Faculty of Medicine [Bern], University of Bern-University of Bern, Saarland University [Saarbrücken], This research was partially funded by the EIT Digital WellbeingActivity 17074, ELEMENT. The data was partially collected during theEU FP7 Dem@Care project, grant agreement 288199. The authors liketo thank Hali Lindsay and Katja Häuser for helpful feedback on anearlier version of the manuscript., Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice)-Université Côte d'Azur (UCA) |
| المصدر: | Neuropsychologia Neuropsychologia, Elsevier, 2019, 131, pp.53-61. ⟨10.1016/j.neuropsychologia.2019.05.007⟩ Neuropsychologia, 2019, 131, pp.53-61. ⟨10.1016/j.neuropsychologia.2019.05.007⟩ |
| بيانات النشر: | Universität des Saarlandes, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Cognitive Neuroscience, Semantic analysis (machine learning), Experimental and Cognitive Psychology, Disease, Semantic speech analysis, Neuropsychological Tests, MCI (mild cognitive impairment), 050105 experimental psychology, Speech Disorders, 03 medical and health sciences, Behavioral Neuroscience, [SCCO]Cognitive science, 0302 clinical medicine, Qualitative analysis, Alzheimer Disease, medicine, Semantic memory, Dementia, Verbal fluency test, Humans, Speech, 0501 psychology and cognitive sciences, Control (linguistics), Aged, Aged, 80 and over, 05 social sciences, Alzheimer's disease, Temporal analysis, medicine.disease, Clinical Practice, Female, Psychology, 030217 neurology & neurosurgery, Cognitive psychology |
| الوصف: | International audience; Contents lists available atScienceDirectNeuropsychologiajournal homepage:www.elsevier.com/locate/neuropsychologiaExploitation vs. exploration—computational temporal and semantic analysisexplains semantic verbalfluency impairment in Alzheimer's diseaseJohannes Trögera,∗, Nicklas Linza, Alexandra Königb, Philippe Robertb, Jan Alexanderssona,Jessica Peterc, Jutta KraydaGerman Research Center for Artificial Intelligence (DFKI), GermanybMemory Center, CoBTeK, IA CHU Université Côte d’Azur, FrancecUniversity Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, SwitzerlanddChair for Development of Language, Learning & Action, University of Saarland, GermanyARTICLE INFOKeywords:Alzheimer's diseaseMCI (mild cognitive impairment)Semantic speech analysisTemporal analysisABSTRACTImpaired Semantic Verbal Fluency (SVF) in dementia due to Alzheimer's Disease (AD) and its precursor MildCognitive Impairment (MCI) is well known. Yet, it remains open whether this impairment mirrors the break-down of semantic memory retrieval processes or executive control processes. Therefore, qualitative analysis ofthe SVF has been proposed but is limited in terms of methodology and feasibility in clinical practice.Consequently, research draws no conclusive picture which of these afore-mentioned processes drives the SVFimpairment in AD and MCI. This study uses a qualitative computational approach—combining temporal andsemantic information—to investigate exploitation and exploration patterns as indicators for semantic memoryretrieval and executive control processes. Audio SVF recordings of 20 controls (C, 66–81 years), 55 MCI (57–94years) and 20 AD subjects (66–82 years) were assessed while groups were matched according to age and edu-cation. All groups produced, on average, the same amount of semantically related items in rapid successionwithin word clusters. Conversely, towards AD, there was a clear decline in semantic as well as temporal ex-ploration patterns between clusters. Results strongly point towards preserved exploitation—semantic memoryretrieval processes—and hampered exploration—executive control processes—in AD and potentially in MCI. |
| اللغة: | English |
| تدمد: | 0028-3932 1873-3514 |
| DOI: | 10.22028/d291-31876 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94614d2fe916c6cf12bab8784723924Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b94614d2fe916c6cf12bab8784723924 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00283932 18733514 |
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| DOI: | 10.22028/d291-31876 |