Prevalence of Human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil
| العنوان: | Prevalence of Human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil |
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| المؤلفون: | Jaila Dias Borges Lalwani, Cynara Melo Gato, Cristóvão Alves da Costa, Lucinei Alves Maciel, Márcia Poinho EncarnaçÃo de Morais, Pritesh Lalwani |
| المصدر: | Revista do Instituto de Medicina Tropical de São Paulo, Vol 59, Iss 0 (2017) Revista do Instituto de Medicina Tropical de São Paulo Revista do Instituto de Medicina Tropical de São Paulo; Vol. 59 (2017); e80 Revista do Instituto de Medicina Tropical de São Paulo; v. 59 (2017); e80 Instituto de Medicina Tropical (IMT) instacron:IMT Revista do Instituto de Medicina Tropical de São Paulo, Volume: 59, Article number: e80, Published: 21 DEC 2017 Repositório Institucional do INPA Instituto Nacional de Pesquisas da Amazônia (INPA) instacron:INPA |
| بيانات النشر: | Universidade de São Paulo, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Enzyme-linked Immunosorbent Assay, Cross-sectional study, viruses, Htlv-1 Infection, Prevalence, Seroprevalence, Human T-lymphotropic virus, 0302 clinical medicine, Seroepidemiologic Studies, immune system diseases, hemic and lymphatic diseases, Prevalence of HTLV, Epidemiology, Medicine, Human T-lymphotropic Virus 1, Human T-lymphotropic Virus 2, Human T-lymphotropic virus 1, Htlv-2 Infection, biology, Isolation And Purification, Human T-lymphotropic virus 2, virus diseases, Middle Aged, Epidemiology of HTLV infection, Female, Original Article, Antibody, Primate T-lymphotropic Virus 2, T-lymphotropic virus type 1 and 2, Brazil, Human, Adult, medicine.medical_specialty, Western Blotting, lcsh:Arctic medicine. Tropical medicine, Adolescent, lcsh:RC955-962, 030231 tropical medicine, Major Clinical Study, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Blood donors, Cross-sectional Studies, 03 medical and health sciences, Young Adult, Virology, Structured Questionnaire, Statistics And Numerical Data, Humans, Seroepidemiology, business.industry, Blood Donor, Brasil, Social Status, HTLV, biology.organism_classification, Htlv-ii Infections, HTLV-I Infections, 030104 developmental biology, Cross-Sectional Studies, HTLV-II Infections, biology.protein, Cross-sectional Study, business, HTLV subtyping, HTLV1, HTLV2 |
| الوصف: | Introduction: Human T-lymphotropic virus type 1 and 2 (HTLV-1/2) is endemic in Brazil, but few studies have investigated the seroprevalence of HTLV and its subtypes among blood donors in the capital city Manaus, Amazonas State, Brazil. Aim: To estimate the seroprevalence of HTLV-1/2 and to identify circulating subtypes among blood donors in Manaus. Materials and Methods: Blood donors (2001-2003) were screened for HTLV-1/2 antibodies by ELISA. Positive results were confirmed and subtyped by Western blot assays. Prevalence rates were calculated and compared with demographic data. Results: Among the 87,402 individuals screened, 116 (0.13%) were seropositive for HTLV-1/2. A second sample (76/116) was collected and retested by HTLV-1/2 ELISA, of which only 41/76 were positive. Western blot confirmed HTLV infection in 24/41 retested blood donors [HTLV-1 (n=16), HTLV-2 (n=5) and HTLV-untypable (n=3)]. Discussion: HTLV-1 and HTLV-2 are prevalent among blood donors in Manaus. However, additional studies are needed to comprehend the epidemiology of HTLV-1/2 in Amazonas not only to understand the pathophysiology of the disease providing adequate medical assistance, but also to reduce or block virus transmission. © 2017, Instituto de Medicina Tropical de Sao Paulo. All rights reserved. |
| وصف الملف: | application/pdf; text/html |
| اللغة: | English |
| تدمد: | 1678-9946 0036-4665 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbea801d248d7551813033b945c3a79eTest http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000248&lng=en&tlng=enTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fbea801d248d7551813033b945c3a79e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16789946 00364665 |
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