Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

التفاصيل البيبلوغرافية
العنوان:	Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers
المؤلفون:	Kirchhoff, T, McGuffog, L, Wang, X, Chen, X, Beesley, J, Soucy, P, Kuchenbaecker, KB, Ramus, SJ, Antoniou, AC, Gaudet, MM, Couch, FJ, MeijersHeijboer, HEJ, Chung, WK, John, EM, Miron, A, Southey, MC, Hopper, JL, Goldgar, DE, Singer, CF, Rappaport, C, Tea, MKM, FinkRetter, A, Barrowdale, D, Hansen, TVO, Nielsen, FC, Arason, A, Vijai, J, Shah, S, Sarrel, K, Robson, ME, Piedmonte, M, Phillips, K, Basil, J, Lee, A, Rubinstein, WS, Boggess, J, Wakeley, K, EwartToland, A, Montagna, M, Agata, S, Imyanitov, EN, Isaacs, C, Janavicius, R, Lazaro, C, Healey, S, Blanco, I, Feliubadalo, L, Brunet, J, Gayther, SA, Pharoah, PPD, Odunsi, KO, Karlan, BY, Walsh, CS, Olah, E, Teo, SH, Sinilnikova, OM, Ganz, PA, Beattie, MS, Van Rensburg, EJ, Dorfling, CM, Diez, O, Kwong, A, Schmutzler, RK, Wappenschmidt, B, Engel, C, Meindl, A, Andrulis, IL, Ditsch, N, Arnold, N, Heidemann, S, Niederacher, D, PreislerAdams, S, Gadzicki, D, VaronMateeva, R, Deissler, H, Gehrig, A, Sutter, C, Ozcelik, H, Kast, K, Fiebig, B, Heinritz, W, Caldes, T, De La Hoya, M, Muranen, TA, Nevanlinna, H, Tischkowitz, MD, Spurdle, AB, Neuhausen, SL, Mulligan, AM, Ding, YC, Lindor, NM, Fredericksen, Z, Pankratz, VS, Peterlongo, P, Manoukian, S, Peissel, B, Zaffaroni, D, Barile, M, Bernard, L, Thomassen, M, Viel, A, Giannini, G, Varesco, L, Radice, P, Greene, MH, Mai, PL, Easton, DF, ChenevixTrench, G, Offit, K, Simard, J, Gerdes, AM, Jensen, UB, Skytte, AB, Kruse, TA, Caligo, MA, Von Wachenfeldt, A, BarbanyBustinza, G, Loman, N, Soller, M, Ehrencrona, H, Karlsson, P, Nathanson, K, Rebbeck, TR, Domchek, SM, Jakubowska, A, Lubinski, J, Jaworska, K, Durda, K, Zołwocka, E, Huzarski, T, Byrski, T, Gronwald, J, Cybulski, C, Goŕski, B, Osorio, A, Durań, M, Tejada, MI, Benitez, J, Hamann, U, Hogervorst, FBL, Van Os, TA, Van Leeuwen, FE, Wijnen, J, Blok, MJ, Kets, M, Hooning, MJ, Oldenburg, RA, Ausems, MGEM, Peock, S, Frost, D, Ellis, SD, Platte, R, Fineberg, E, Evans, DG, Jacobs, C, Eeles, RA, Adlard, J, Davidson, R, Eccles, DM, Cole, T, Cook, J, Paterson, J, Brewer, C, Douglas, F, Hodgson, SV, Morrison, PJ, Walker, L, Porteous, ME, Kennedy, MJ, Side, LE, Bove, B, Godwin, AK, StoppaLyonnet, D, FassyColcombet, M, Castera, L, Cornelis, F, Mazoyer, S, Leóne, M, BoutryKryza, N, Bressacde Paillerets, B, Caron, O, Pujol, P, Coupier, I, Delnatte, C, Akloul, L, Lynch, HT, Snyder, CL, Buys, SS, Daly, MB, Terry, M
بيانات النشر:	American Association for Cancer Research. United States
سنة النشر:	2012
المجموعة:	University of Hong Kong: HKU Scholars Hub
مصطلحات موضوعية:	BRCA2 Protein - genetics, Chromosomes, Human, Pair 19 - genetics, Ovarian Neoplasms - epidemiology - genetics - metabolism, BRCA1 Protein - genetics, Breast Neoplasms - epidemiology - genetics - metabolism
الوصف:	Background: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Methods: Genotyping data for 12,599 BRCA1 and 7,132 BRCA2 mutation carriers from 40 studies were combined. Results: We confirmed associations between rs8170 at 19p13.1 and breast cancer risk for BRCA1 mutation carriers [HR, 1.17; 95% confidence interval (CI), 1.07-1.27; P = 7.42 × 10 -4] and between rs16917302 at ZNF365 (HR, 0.84; 95% CI, 0.73-0.97; P = 0.017) but not rs311499 at 20q13.3 (HR, 1.11; 95% CI, 0.94-1.31; P = 0.22) and breast cancer risk for BRCA2 mutation carriers. Analyses based on tumor histopathology showed that 19p13 variants were predominantly associated with estrogen receptor (ER)-negative breast cancer for both BRCA1 and BRCA2 mutation carriers, whereas rs16917302 at ZNF365 was mainly associated with ER-positive breast cancer for both BRCA1 and BRCA2 mutation carriers.Wealso found for the first time that rs67397200 at 19p13.1 was associated with an increased risk of ovarian cancer for BRCA1 (HR, 1.16; 95% CI, 1.05-1.29; P = 3.8 × 10 -4) and BRCA2 mutation carriers (HR, 1.30; 95% CI, 1.10-1.52; P = 1.8 × 10 -3). Conclusions: 19p13.1 and ZNF365 are susceptibility loci for ovarian cancer and ER subtypes of breast cancer among BRCA1 and BRCA2 mutation carriers. Impact: These findings can lead to an improved understanding of tumor development and may prove useful for breast and ovarian cancer risk prediction for BRCA1 and BRCA2 mutation carriers. © 2012 AACR. ; link_to_OA_fulltext
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
تدمد:	1055-9965
العلاقة:	Cancer Epidemiology Biomarkers and Prevention; http://www.scopus.com/mlt/select.url?eid=2-s2.0-84859377440&selection=ref&src=s&origin=recordpageTest; Cancer Epidemiology Biomarkers And Prevention, 2012, v. 21 n. 4, p. 645-657; 657; 198692; WOS:000302220600010; PMC3319317; eid_2-s2.0-84859377440; 645; http://hdl.handle.net/10722/182270Test; 21
DOI:	10.1158/1055-9965.EPI-11-0888
الإتاحة:	https://doi.org/10.1158/1055-9965.EPI-11-0888Test http://hdl.handle.net/10722/182270Test
رقم الانضمام:	edsbas.9302DF2D
قاعدة البيانات:	BASE

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الوصف
تدمد:	10559965
DOI:	10.1158/1055-9965.EPI-11-0888