دورية أكاديمية
IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma
| العنوان: | IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma |
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| المؤلفون: | Cairns, RA, Iqbal, J, Lemonnier, F, Kucuk, C, de Leval, L, Jais, JP, Parrens, M, Martin, A, Xerri, L, Brousset, P, Chan, WC, Gaulard, P, Mak, TW, Chan, LC |
| بيانات النشر: | //bloodjournal.hematologylibrary.org/ United States |
| سنة النشر: | 2012 |
| المجموعة: | University of Hong Kong: HKU Scholars Hub |
| مصطلحات موضوعية: | Lymphoma, T-Cell, Peripheral - enzymology - genetics - pathology, Immunoblastic Lymphadenopathy - enzymology - genetics - pathology, Isocitrate Dehydrogenase - genetics, Mutation, T-Cell - enzymology - genetics - pathology |
| الوصف: | Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) occur in most grade 2 and 3 gliomas, secondary glioblastomas, and a subset of acute myelogenous leukemias but have not been detected in other tumor types. The mutations occur at specific arginine residues and result in the acquisition of a novel enzymatic activity that converts 2-oxoglutarate to D-2-hydroxyglutarate. This study reports IDH1 and IDH2 genotyping results from a set of lymphomas, which included a large set of peripheral T-cell lymphomas. IDH2 mutations were identified in approximately 20% of angioimmunoblastic T-cell lymphomas (AITLs), but not in other peripheral T-cell lymphoma entities. These results were confirmed in an independent set of AITL patients, where the IDH2 mutation rate was approximately 45%. This is the second common genetic lesion identified in AITL after TET2 and extends the number of neoplastic diseases where IDH1 and IDH2 mutations may play a role. ; link_to_OA_fulltext |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-00-300713-8 0-00-300713-8 |
| تدمد: | 1528-0020 0006-4971 |
| العلاقة: | Blood; Blood, 2012, v. 119 n. 8, p. 1901-1903; 1903; 206273; WOS:000300713800019; PMC3293643; eid_2-s2.0-84857575341; 1901; http://hdl.handle.net/10722/164835Test; 119 |
| DOI: | 10.1182/blood-2011-11-391748 |
| الإتاحة: | https://doi.org/10.1182/blood-2011-11-391748Test http://hdl.handle.net/10722/164835Test |
| حقوق: | This research was originally published in The Hematologist: ASH News and Reports. Author(s). Title. The Hematologist: ASH News and Reports. Year;Vol,Issue:pp-pp. © the American Society of Hematology. |
| رقم الانضمام: | edsbas.10C88ACD |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9780003007138 0003007138 |
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| تدمد: | 15280020 00064971 |
| DOI: | 10.1182/blood-2011-11-391748 |