دورية أكاديمية
Correlation between inhalant allergen-specific IgE and pulmonary function in children with asthma
| العنوان: | Correlation between inhalant allergen-specific IgE and pulmonary function in children with asthma |
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| المساهمون: | Sung-Yon Choi, Myung Hyun Sohn, Hye-Yung Yum, Byoung-Chul Kwon, Kyu-Earn Kim, Kwon, Byoung Chul, Kim, Kyu Earn, Son, Myung Hyun, Choi, Sung Yon |
| بيانات النشر: | Wiley-Liss United States |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Administration, Inhalation, Adolescent, Allergens/administration & dosage, Asthma/diagnosis, Asthma/immunology, Asthma/physiopathology, Bronchial Provocation Tests, Child, Female, Forced Expiratory Flow Rates/drug effects, Forced Expiratory Flow Rates/physiology, Humans, Immunoglobulin E/administration & dosage, Korea, Male, Pulmonary Ventilation/drug effects, Pulmonary Ventilation/physiology, Pyroglyphidae/immunology, Retrospective Studies, Severity of Illness Index, Spirometry, Vital Capacity/drug effects, Vital Capacity/physiology, house dust mite, asthma, inhalant allergen, pulmonary function test, specific IgE |
| الوصف: | Sensitization to aeroallergens is associated with diminished lung function in adults. Little has been studied on the relationship between the inhalant allergen-specific IgE and pulmonary function in asthmatic children. This study was focused on four major inhalant allergens found in Korea, including Dermatophagoides pteronyssinus (Der p.), Dermatophagoides farinae (Der f.), and Alternaria- and German cockroach-specific IgEs, with evaluation of pulmonary function in relation to the amount of allergens. The parents or legal guardians of participants enrolled in this study gave informed consent. Fifty-five asthmatic patients and 48 nonasthmatic children were included. The amounts of specific IgE for the four specified inhalant allergens were determined by employing the CAP system FEIA. Forced expiratory volume in 1 sec (FEV1)/forced vital capacity (FVC), FEV1, and forced expiratory flow between 25% and 75% of FVC (FEF25��75) of subjects were evaluated through pulmonary function tests. In the asthmatic group, FEV1, FEV1/FVC, and FEF25��75 were significantly reduced (P��<��0.05): reduction in FEV1 (r��=�됤닋0.44) and FEF25��75 (r��=�됤닋0.33) in association with the Der f.-specific allergen, and reduction in FEV1 (r��=�됤닋0.37) and FEF25��75 (r��=�됤닋0.34) in association with the Der p.-specific allergen, were observed. However, there was no significant correlation with German cockroach and Alternaria allergen. In the control group, no significant correlation was detectable between the allergen-specific IgE titers and the results of pulmonary function tests. In asthmatic patients, Der p.- and Der f.-specific IgEs, and not German cockroach and Alternaria, seem to play a considerable role in reduced pulmonary function among asthmatic children. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 8755-6863 1099-0496 |
| العلاقة: | PEDIATRIC PULMONOLOGY; J02491; OAK-2005-10230; https://ir.ymlib.yonsei.ac.kr/handle/22282913/147332Test; T200500073; PEDIATRIC PULMONOLOGY, Vol.39(2) : 150-155, 2005 |
| DOI: | 10.1002/ppul.20163 |
| DOI: | 10.1002/ppul.20163/abstract |
| الإتاحة: | https://doi.org/10.1002/ppul.20163Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/147332Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.57A73FE7 |
| قاعدة البيانات: | BASE |
| تدمد: | 87556863 10990496 |
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| DOI: | 10.1002/ppul.20163 |