دورية أكاديمية
Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese
| العنوان: | Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese |
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| المؤلفون: | Mok, MY, Lau, CS, Yang, W, Lau, YL, Lee, PPW, Chan, TM, Wong, RWS, Ng, P, Zhao, M, Hirankarn, N, Wong, WHS, Ho, MHK, Lee, TL, Avihingsanon, Y, Wong, SN, Lee, KW, Mok, CC |
| بيانات النشر: | //www.nature.com/gene United Kingdom |
| سنة النشر: | 2009 |
| المجموعة: | University of Hong Kong: HKU Scholars Hub |
| مصطلحات موضوعية: | Middle Aged, Male, Lupus Erythematosus, Systemic - genetics, Linkage Disequilibrium, Intracellular Signaling Peptides and Proteins - genetics, Humans, Hong Kong, Genotype, STAT4 Transcription Factor - genetics, Female, Adult, Genetic Predisposition to Disease, Protein-Serine-Threonine Kinases - genetics, Polymorphism, Single Nucleotide - genetics, Nerve Tissue Proteins - genetics |
| الوصف: | In this study, we compared the association of several newly discovered susceptibility genes for systemic lupus erythematosus (SLE) between populations of European origin and two Asian populations. Using 910 SLE patients and 1440 healthy controls from Chinese living in Hong Kong, and 278 SLE patients and 383 controls in Thailand, we studied association of STAT4, BLK and PXK with the disease. Our data confirmed association of STAT4 (rs7574865, odds ratio (OR) =1.71, P=3.55 × 10-23) and BLK (rs13277113, OR=0.77, P=1.34 × 10-5) with SLE. It was showed that rs7574865 of STAT4 is also linked to hematologic disorders and potentially some other subphenotypes of the disease. More than one genetic variant in STAT4 were found to be associated with the disease independently in our populations (rs7601754, OR=0.59, P=1.39 × 10-9, and P=0.00034 when controlling the effect of rs7574865). With the same set of samples, however, our study did not detect any significant disease association for PXK, a risk factor for populations of European origin (rs6445975, joint P=0.36, OR=1.06, 95% confidence interval: 0.93-1.21). Our study indicates that some of the susceptibility genes for this disease may be population specific. ; link_to_subscribed_fulltext |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1476-5470 1466-4879 |
| العلاقة: | Genes and Immunity; http://www.scopus.com/mlt/select.url?eid=2-s2.0-67349113436&selection=ref&src=s&origin=recordpageTest; Genes And Immunity, 2009, v. 10 n. 3, p. 219-226; 4089029; 226; 155947; 162918; WOS:000265961300003; eid_2-s2.0-67349113436; 219; http://hdl.handle.net/10722/91602Test; 10 |
| DOI: | 10.1038/gene.2009.1 |
| الإتاحة: | https://doi.org/10.1038/gene.2009.1Test http://hdl.handle.net/10722/91602Test |
| رقم الانضمام: | edsbas.C67FA01 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14765470 14664879 |
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| DOI: | 10.1038/gene.2009.1 |