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Taxonomic signatures of cause-specific mortality risk in human gut microbiome

التفاصيل البيبلوغرافية
العنوان: Taxonomic signatures of cause-specific mortality risk in human gut microbiome
المؤلفون: Humphrey Gregory C., Inouye Michael, Salomaa Veikko, Cheng Susan, Sanders Karenina, Watrous Jeramie D., Long Tao, Knight Rob, Valsta Liisa, Alfthan Georg, Laitinen Ville, Meric Guillaume, Sanders Jon G., Niiranen Teemu, Salosensaari Aaro, Jain Mohit, Lahti Leo, Perola Markus, Havulinna Aki S., Brennan Caitriona, Jousilahti Pekka, Salido Rodolfo A.
المساهمون: sisätautioppi, Internal Medicine, data-analytiikka, Data-analytiikka, sovellettu matematiikka, Applied Mathematics, tyks, vsshp, tyks, vsshp, 2607318, 2606102, 2610301
بيانات النشر: Nature Research
Britannia
United Kingdom
GB
سنة النشر: 2022
المجموعة: University of Turku: UTUPub / Turun yliopisto
الوصف: The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally linked to various lifestyle factors and diseases. In spite of these advances, prospective associations between microbiome composition and health have remained uncharacterised due to the lack of sufficiently large and representative population cohorts with comprehensive follow-up data. Here, we analyse the long-term association between gut microbiome variation and mortality in a well-phenotyped and representative population cohort from Finland (n = 7211). We report robust taxonomic and functional microbiome signatures related to the Enterobacteriaceae family that are associated with mortality risk during a 15-year follow-up. Our results extend previous cross-sectional studies, and help to establish the basis for examining long-term associations between human gut microbiome composition, incident outcomes, and general health status.
نوع الوثيقة: other/unknown material
اللغة: English
تدمد: 20210930
2041-1723
العلاقة: 12; 2671; Nature Communications; https://www.utupub.fi/handle/10024/160104Test; https://www.nature.com/articles/s41467-021-22962-yTest; URN:NBN:fi-fe2021093048282
الإتاحة: https://www.utupub.fi/handle/10024/160104Test
https://www.nature.com/articles/s41467-021-22962-yTest
رقم الانضمام: edsbas.AC5AA1
قاعدة البيانات: BASE
الوصف
تدمد:20210930
20411723