Islet-cell antibodies in IDDM and NIDDM in a Japanese population
| العنوان: | Islet-cell antibodies in IDDM and NIDDM in a Japanese population |
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| المؤلفون: | Tokuji Itoh, Tadao Sugimoto, Kinori Kosaka, Toshiaki Tanaka, Shinji Sawano, Tetsuro Kobayashi, Seizo Suwa |
| المصدر: | The Tohoku Journal of Experimental Medicine. 141:271-274 |
| بيانات النشر: | Tohoku University Medical Press, 1983. |
| سنة النشر: | 1983 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, medicine.medical_specialty, Time Factors, endocrine system diseases, medicine.medical_treatment, Cell, Thyroid Gland, Disease, General Biochemistry, Genetics and Molecular Biology, Islets of Langerhans, Japan, Internal medicine, Diabetes mellitus, medicine, Humans, Autoantibodies, geography, geography.geographical_feature_category, biology, business.industry, Insulin, Thyroid, nutritional and metabolic diseases, General Medicine, Middle Aged, Japanese population, Islet, medicine.disease, Diabetes Mellitus, Type 1, Endocrinology, medicine.anatomical_structure, Diabetes Mellitus, Type 2, biology.protein, Female, Antibody, business |
| الوصف: | Islet-cell antibodies (ICA) were studied in 538 Japanese diabetics with insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM). The overall prevalence of ICA was 17% (16/93), 4% (7/164), 2% (2/90) and 3% (5/191) in IDDM, NIDDM treated with insulin, NIDDM treated with oral hypoglycemic agents, and NIDDM treated by diet alone, respectively. ICA were detected in 58% (11/19) of patients with IDDM in the first year of the disease. The prevalence of ICA decreased drastically with prolongation of the disease. We could not find any ICA-positive IDDM in subjects with a clinical course of more than 10 years. The level of thyroid microsomal antibodies was not significantly higher in either type of diabetes when compared to nondiabetic controls. These results suggest that Japanese diabetics may have a weaker autoimmune predisposition than Caucasians. |
| تدمد: | 1349-3329 0040-8727 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876319a823ecac15d5a62f439f0cb9b2Test https://doi.org/10.1620/tjem.141.suppl_271Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....876319a823ecac15d5a62f439f0cb9b2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13493329 00408727 |
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