دورية أكاديمية
Noncoding RNA in Cholangiocarcinoma.
| العنوان: | Noncoding RNA in Cholangiocarcinoma. |
|---|---|
| المؤلفون: | Salati, M, Braconi, C |
| المساهمون: | Braconi, Chiara |
| بيانات النشر: | THIEME MEDICAL PUBL INC |
| سنة النشر: | 2019 |
| المجموعة: | The Institute of Cancer Research (ICR): Publications Repository |
| مصطلحات موضوعية: | Humans, Cholangiocarcinoma, Bile Duct Neoplasms, Liver Neoplasms, MicroRNAs, Gene Expression Regulation, Neoplastic, Tumor Microenvironment, RNA, Long Noncoding, Carcinogenesis |
| الوصف: | Cholangiocarcinomas (CCAs) are tumors with a dismal prognosis. Early diagnosis is a key challenge because of the lack of specific symptoms, and the curability rate is low due to the difficulty in achieving a radical resection and the intrinsic chemoresistance of CCA cells. Noncoding RNAs (ncRNAs) are transcripts that are not translated into proteins but exert their functional role by regulating the transcription and translation of other genes. The discovery of the first ncRNA dates back to 1993 when the microRNA (miRNA) lin-4 was discovered in Caenorhabditis elegans. Only 10 years later, miRNAs were shown to play an oncogenic role in cancer cells and within 20 years miRNA therapeutics were tested in humans. Here, the authors review the latest evidence for a role for ncRNAs in CCA and discuss the promise and challenges associated with the introduction of ncRNAs into clinical practice. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; 25; application/pdf |
| اللغة: | English |
| تدمد: | 0272-8087 1098-8971 |
| العلاقة: | Seminars in liver disease, 2019, 39 (1), pp. 13 - 25; https://repository.icr.ac.uk/handle/internal/3190Test |
| DOI: | 10.1055/s-0038-1676097 |
| الإتاحة: | https://doi.org/10.1055/s-0038-1676097Test https://repository.icr.ac.uk/handle/internal/3190Test |
| حقوق: | https://www.rioxx.net/licenses/under-embargo-all-rights-reservedTest |
| رقم الانضمام: | edsbas.CE4D409D |
| قاعدة البيانات: | BASE |
| تدمد: | 02728087 10988971 |
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| DOI: | 10.1055/s-0038-1676097 |