التفاصيل البيبلوغرافية
| العنوان: |
DJ-1 as a Modulator of Autophagy: An Hypothesis |
| المؤلفون: |
Rosa A. González-Polo, Mireia Niso-Santano, Ruben Gómez-Sánchez, Jose M. Bravo-San Pedro, José M. Fuentes |
| بيانات النشر: |
TheScientificWorldJOURNAL |
| سنة النشر: |
2010 |
| المجموعة: |
Hindawi Publishing Corporation |
| مصطلحات موضوعية: |
Neurology |
| الوصف: |
The etiology of Parkinson's disease (PD) is not completely defined, although environmental factors (for example, exposure to the herbicide paraquat [PQ]) and genetic susceptibility (such as DJ-1 mutations that have been associated with an autosomal-recessive form of early-onset PD) have been demonstrated to contribute. Alterations in macroautophagy have been described in the pathogenesis of this neurodegenerative disease. We have established a model system to study the involvement of the DJ-1 protein in PQ-induced autophagy. When we transfected cells exposed to PQ with DJ-1–specific siRNA, we observed an inhibition of the autophagic events induced by the herbicide, as well as sensitization additive with PQ-induced apoptotic cell death and exacerbation of this cell death in the presence of the autophagy inhibitor 3-methyladenine. These results suggest, for the first time, an active role for DJ-1 in the autophagic response produced by PQ, opening the door to new strategies for PD therapy. |
| نوع الوثيقة: |
other/unknown material |
| اللغة: |
English |
| العلاقة: |
https://doi.org/10.1100/tsw.2010.165Test |
| DOI: |
10.1100/tsw.2010.165 |
| الإتاحة: |
https://doi.org/10.1100/tsw.2010.165Test |
| حقوق: |
Copyright © 2010 Rosa A. González-Polo et al. |
| رقم الانضمام: |
edsbas.3EE912D2 |
| قاعدة البيانات: |
BASE |
