التفاصيل البيبلوغرافية
| العنوان: |
The effects of the neonicotinoid imidacloprid on gene expression and DNA methylation in the buff-tailed bumblebee Bombus terrestris |
| المؤلفون: |
Bebane, P. S. A., Hunt, B. J., Pegoraro, M., Jones, A. R. C, Marshall, H., Rosato, E., Mallon, E. B. |
| المساهمون: |
Natural Environment Research Council |
| المصدر: |
Proceedings of the Royal Society B: Biological Sciences ; volume 286, issue 1905, page 20190718 ; ISSN 0962-8452 1471-2954 |
| بيانات النشر: |
The Royal Society |
| سنة النشر: |
2019 |
| الوصف: |
Neonicotinoids are effective insecticides used on many important arable and horticultural crops. They are nicotinic acetylcholine receptor agonists which disrupt the function of insect neurons and cause paralysis and death. In addition to direct mortality, there are numerous sublethal effects of low doses of neonicotinoids on bees. We hypothesize that some of these large array of effects could be a consequence of epigenetic changes in bees induced by neonicotinoids. We compared whole methylome (BS-seq) and RNA-seq libraries of the brains of buff-tailed bumblebee Bombus terrestris workers exposed to field-realistic doses of the neonicotinoid imidacloprid to libraries from control workers. We found numerous genes which show differential expression between neonicotinoid-treated bees and control bees, but no differentially methylated cytosines in any context. We found CpG methylation to be focused mainly in exons and associated with highly expressed genes. We discuss the implications of our results for future legislation. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1098/rspb.2019.0718 |
| الإتاحة: |
https://doi.org/10.1098/rspb.2019.0718Test |
| حقوق: |
https://royalsociety.org/journals/ethics-policies/data-sharing-miningTest/ |
| رقم الانضمام: |
edsbas.B6C1CB0D |
| قاعدة البيانات: |
BASE |
