A peripheral CD4+ T cell precursor for naive, memory, and regulatory T cells
| العنوان: | A peripheral CD4+ T cell precursor for naive, memory, and regulatory T cells |
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| المؤلفون: | Chunfang Zhao, Joanna D. Davies |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | The Rockefeller University Press, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Regulatory T cell, T cell, Immunology, Receptors, Antigen, T-Cell, Mice, SCID, Biology, CD5 Antigens, T-Lymphocytes, Regulatory, Article, Interleukin-7 Receptor alpha Subunit, 03 medical and health sciences, Interleukin 21, Mice, 0302 clinical medicine, T-Lymphocyte Subsets, medicine, Immunology and Allergy, Cytotoxic T cell, Animals, IL-2 receptor, Lymphocyte Count, Antigen-presenting cell, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Mice, Inbred BALB C, Precursor Cells, T-Lymphoid, CD28, Forkhead Transcription Factors, respiratory system, Natural killer T cell, Flow Cytometry, Adoptive Transfer, 3. Good health, Cell biology, medicine.anatomical_structure, Hyaluronan Receptors, Proto-Oncogene Proteins c-bcl-2, Interleukin-2, human activities, Immunologic Memory, 030215 immunology |
| الوصف: | CD4+ T cells expressing very low amounts of CD44 on their surface act as peripheral precursors of a diverse CD4+ T cell pool. Mechanisms that control the size of the T cell pool, the ratio between naive cells and memory cells, the number and frequency of regulatory T cells, and T cell receptor (TCR) diversity are necessary to maintain immune integrity and avoid disease. We have previously shown that a subset of naive CD4+ T cells, defined by the expression on their surface of a very low density of CD44 (CD44v.low cells), can inhibit wasting and wasting-associated lymphopenia in mice with cancer. In this study, we further investigate the properties of CD44v.low cells and show that they are significantly more efficient than the remaining naive (CD44low or CD44int) and memory CD4+ cell subsets in reconstituting the overall size of the CD4+ T cell pool, creating a T cell pool with a diverse TCR repertoire, generating regulatory T cells that express forkhead box P3 (FoxP3), and promoting homeostatic equilibrium between naive, memory, and Foxp3+ regulatory T cell numbers. T cell population reconstitution by CD44v.low cells is thymus independent. Compared with CD44int cells, a higher percentage of CD44v.low cells express B cell leukemia/lymphoma 2, interleukin-7 receptor, and CD5. The data support a key role for CD4+ CD44v.low cells as peripheral precursors that maintain the integrity of the CD4+ T cell pool. |
| اللغة: | English |
| تدمد: | 1540-9538 0022-1007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0dabe8e37e93257153fb103d5bfa21Test http://europepmc.org/articles/PMC3005223Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ae0dabe8e37e93257153fb103d5bfa21 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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