Constructing a Golgi complex
| العنوان: | Constructing a Golgi complex |
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| المؤلفون: | Suzanne R. Pfeffer |
| المصدر: | The Journal of Cell Biology |
| بيانات النشر: | The Rockefeller University Press, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Endosome, Molecular Sequence Data, Golgi Apparatus, Biology, Kidney, Autoantigens, symbols.namesake, Mice, Report, Two-Hybrid System Techniques, Yeasts, Animals, Humans, Secretory pathway, Vesicular-tubular cluster, Endoplasmic reticulum, Comment, Golgi Matrix Proteins, Membrane Proteins, Cell Biology, COPI, Golgi apparatus, protein transport, rab GTPases, rab2, Golgi stacks, Cell biology, Transport protein, Rats, Protein Transport, rab2 GTP-Binding Protein, symbols, Medial Golgi, HeLa Cells |
| الوصف: | Membrane traffic between the endoplasmic reticulum (ER) and Golgi apparatus and through the Golgi apparatus is a highly regulated process controlled by members of the rab GTPase family. The GTP form of rab1 regulates ER to Golgi transport by interaction with the vesicle tethering factor p115 and the cis-Golgi matrix protein GM130, also part of a complex with GRASP65 important for the organization of cis-Golgi cisternae. Here, we find that a novel coiled-coil protein golgin-45 interacts with the medial-Golgi matrix protein GRASP55 and the GTP form of rab2 but not other Golgi rab proteins. Depletion of golgin-45 disrupts the Golgi apparatus and causes a block in secretory protein transport. These results demonstrate that GRASP55 and golgin-45 form a rab2 effector complex on medial-Golgi essential for normal protein transport and Golgi structure. |
| اللغة: | English |
| تدمد: | 1540-8140 0021-9525 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddb73468213f608f8c8e1e55ceceb0aTest http://europepmc.org/articles/PMC2150916Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8ddb73468213f608f8c8e1e55ceceb0a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15408140 00219525 |
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