رسالة جامعية
Prospective Cohort Study of Fatal Lung Cancer, Inflammation, Smoking and Lifestyle Risk Factors: Results from the Third National Health and Nutrition Examination Survey
| العنوان: | Prospective Cohort Study of Fatal Lung Cancer, Inflammation, Smoking and Lifestyle Risk Factors: Results from the Third National Health and Nutrition Examination Survey |
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| المؤلفون: | Bittoni, Marisa Anna |
| بيانات النشر: | The Ohio State University / OhioLINK, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | Ohiolink ETDs |
| Original Material: | http://rave.ohiolink.edu/etdc/view?acc_num=osu1374074945Test |
| مصطلحات موضوعية: | Epidemiology, Health Sciences, Public Health, Nutrition, Inflammation, lung cancer, c-reactive protein, smoking, diet, obesity, physical activity |
| الوصف: | Background: C-reactive protein (CRP), a biomarker of inflammation, is an acute-phase protein that displays a rapid and distinct rise in plasma concentration in response to acute inflammation, infection and tissue damage. CRP levels have been found to be moderately elevated in individuals with lung cancer. Few studies have examined associations between lung cancer, CRP, and other inflammatory factors, and these studies have not shown consistent results. The primary goals of this study were to: 1) prospectively examine the overall association between CRP and fatal lung cancer; 2) examine the effect of modifiable lifestyle factors, such as diet and physical activity on this relationship; and 3) examine the effects of demographic and other lifestyle risk factors, such as age, gender, race, smoking and obesity on inflammation and fatal lung cancer. Secondary goals were to examine the effect of demographic and lifestyle factors on CRP.Methods: Data from cancer-free individuals over age 40 in the Third National Health and Nutrition Examination Survey (NHANESIII:1988-1994) were examined prospectively in relation to inflammatory factors and fatal lung cancer. Mortality status was ascertained through probabilistic record matching using the National Death Index, with mortality follow-up through 2006. Baseline demographic and clinical data were acquired from interviews and laboratory examinations. Cox proportional hazards regression assessed factors related to inflammation and fatal lung cancer. Logistic regression assessed the effect of lifestyle factors on CRP.Results: Of 8,950 participants, 219 individuals died of lung cancer during the 218-month follow-up period. Individuals who died from lung cancer were significantly more likely to be male (66% vs 48%), older (65 vs 61 years), to have elevated serum CRP levels (>3mg/L; 51% vs 39%), lower mean BMI (26 vs 28 kg/m2), and to ever have smoked >100 cigarettes (92% vs 54%). Multivariate regression models revealed a dose-response effect for CRP and fatal lung cancer risk (p-trend7 mg/L (HR=2.44, P |
| Original Identifier: | oai:etd.ohiolink.edu:osu1374074945 |
| نوع الوثيقة: | text |
| اللغة: | English |
| الإتاحة: | http://rave.ohiolink.edu/etdc/view?acc_num=osu1374074945Test |
| حقوق: | unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| رقم الانضمام: | edsndl.OhioLink.oai.etd.ohiolink.edu.osu1374074945 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| الوصف غير متاح. |