التفاصيل البيبلوغرافية
| العنوان: |
Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma. |
| المؤلفون: |
Rajbhandari, Rajani, McFarland, Braden C, Patel, Ashish, Gerigk, Magda, Gray, G Kenneth, Fehling, Samuel C, Bredel, Markus, Berbari, Nicolas F, Kim, Hyunsoo, Marks, Margaret P, Meares, Gordon P, Sinha, Tanvi, Chuang, Jeffrey, Benveniste, Etty N, Nozell, Susan E |
| المصدر: |
Faculty Research 2015 |
| بيانات النشر: |
The Mouseion at the JAXlibrary |
| سنة النشر: |
2015 |
| المجموعة: |
The Jackson Laboratory: The Mouseion at the JAXlibrary |
| مصطلحات موضوعية: |
Life Sciences, Medicine and Health Sciences |
| الوصف: |
Glioblastomas (GBMs) are deadly tumors of the central nervous system. Most GBM exhibit homozygous deletions of the CDKN2A and CDKN2B tumor suppressors at 9p21.3, although loss of CDKN2A/B alone is insufficient to drive gliomagenesis. MIR31HG, which encodes microRNA-31 (miR-31), is a novel non-coding tumor suppressor positioned adjacent to CDKN2A/B at 9p21.3. We have determined that miR-31 expression is compromised in >72% of all GBM, and for patients, this predicts significantly shortened survival times independent of CDKN2A/B status. We show that miR-31 inhibits NF-κB signaling by targeting TRADD, its upstream activator. Moreover, upon reintroduction, miR-31 significantly reduces tumor burden and lengthens survival times in animal models. As such, our work identifies loss of miR-31 as a novel non-coding tumor-driving event in GBM. Oncotarget 2015 Jul 10; 6(19):17805-16. |
| نوع الوثيقة: |
text |
| اللغة: |
unknown |
| العلاقة: |
https://mouseion.jax.org/stfb2015/125Test |
| الإتاحة: |
https://mouseion.jax.org/stfb2015/125Test |
| رقم الانضمام: |
edsbas.E0CBEA4D |
| قاعدة البيانات: |
BASE |
