دورية أكاديمية
IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans.
| العنوان: | IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans. |
|---|---|
| المؤلفون: | Schmitt, Nathalie, Bustamante, Jacinta, Bourdery, Laure, Bentebibel, Salah Eddine, Boisson-Dupuis, Stephanie, Hamlin, Fran, Tran, Mau V, Blankenship, Derek, Pascual, Virginia, Savino, Daniel A, Banchereau, Jacques, Casanova, Jean-Laurent, Ueno, Hideki |
| المصدر: | Faculty Research 2013 |
| بيانات النشر: | The Mouseion at the JAXlibrary |
| سنة النشر: | 2013 |
| المجموعة: | The Jackson Laboratory: The Mouseion at the JAXlibrary |
| مصطلحات موضوعية: | Adolescent, Adult, Blotting, Western, Case-Control Studies, Child, Preschool, Flow Cytometry, Fluorescent Antibody Technique, Germinal Center, Humans, Immunoenzyme Techniques, Immunologic Memory, Interleukin-12, Interleukin-23, Lymph Nodes, Palatine Tonsil, Phosphorylation, Plasma Cells, Receptors, STAT4 Transcription Factor, T-Lymphocyte Subsets, T-Lymphocytes, Helper-Inducer, Young Adult, Life Sciences, Medicine and Health Sciences |
| الوصف: | Antibody responses represent a key immune protection mechanism. T follicular helper (Tfh) cells are the major CD4(+) T-cell subset that provides help to B cells to generate an antibody response. Tfh cells together with B cells form germinal centers (GCs), the site where high-affinity B cells are selected and differentiate into either memory B cells or long-lived plasma cells. We show here that interleukin-12 receptor β1 (IL-12Rβ1)-mediated signaling is important for in vivo Tfh response in humans. Although not prone to B cell-deficient-associated infections, subjects lacking functional IL-12Rβ1, a receptor for IL-12 and IL-23, displayed substantially less circulating memory Tfh and memory B cells than control subjects. GC formation in lymph nodes was also impaired in IL-12Rβ1-deficient subjects. Consistently, the avidity of tetanus toxoid-specific serum antibodies was substantially lower in these subjects than in age-matched controls. Tfh cells in tonsils from control individuals displayed the active form of signal transducer and activator of transcription 4 (STAT4), demonstrating that IL-12 is also acting on Tfh cells in GCs. Thus, our study shows that the IL-12-STAT4 axis is associated with the development and the functions of Tfh cells in vivo in humans. Blood 2013 Apr 25; 121(17):3375-85 |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://mouseion.jax.org/stfb2013/128Test; http://bloodjournal.hematologylibrary.org/content/121/17/3375.abstractTest |
| الإتاحة: | https://mouseion.jax.org/stfb2013/128Test http://bloodjournal.hematologylibrary.org/content/121/17/3375.abstractTest |
| رقم الانضمام: | edsbas.B1EDADB2 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |