Metastatic axillary node ratio predicts recurrence and poor long-term prognosis in patients with advanced stage IIIC (pN3) breast cancer
| العنوان: | Metastatic axillary node ratio predicts recurrence and poor long-term prognosis in patients with advanced stage IIIC (pN3) breast cancer |
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| المؤلفون: | Min Hee Hur, SeungSang Ko |
| المصدر: | Annals of Surgical Treatment and Research |
| بيانات النشر: | The Korean Surgical Society, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Multivariate analysis, Survival, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Internal medicine, medicine, 030212 general & internal medicine, Stage (cooking), Risk factor, Lymph node, Lymph nodes, business.industry, Medical record, Cancer, medicine.disease, Prognosis, Axilla, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Surgery, Original Article, Breast neoplasms, business |
| الوصف: | PURPOSE Patients with stage IIIC breast cancer are classified as having pathologic nodal stage 3 (pN3) according to the 7th American Joint Committee on Cancer Tumor Node Metastasis (AJCC TNM) staging system. However, the prognosis of patients with this stage is still highly variable. This study was carried out to investigate the validity of metastatic axillary lymph node ratio (mALNR) as a predictor of long-term prognosis in stage IIIC breast cancer. METHODS Medical records of 297 patients who underwent surgery with more than level II axillary dissection for breast cancer and who were diagnosed with pN3 by pathology between 1990 and 2010, were reviewed. Clinicopathologic variables were evaluated as prognostic factors of disease-free and overall survival by univariate and multivariate analyses. RESULTS A preliminary analysis revealed the cutoff value of mALNR to be 0.65 (Low65 group vs. High65 group). The mean mALNR was 0.62 (0.16-1.0) and was the most significant independent predictor of disease-free and overall survival on multivariate analysis. The rates of recurrence were significantly different according to mALNR (Low65, 40.3%; High65, 63.0%; P < 0.001). The 10-year disease-free (Low65, 57.0%; High65, 35.0%) and overall (Low65, 64.2%; High65, 38.3%) survival rates decreased significantly with increased mALNR (P < 0.001). CONCLUSION Patients with stage IIIC breast cancer can be subdivided into subgroups with significantly different long-term prognoses. Our data suggest that the mALNR is an independent risk factor of recurrence and mortality. The mALNR is a valuable prognostic factor to predict the long-term prognosis of stage IIIC breast cancer patients. |
| اللغة: | English |
| تدمد: | 2288-6796 2288-6575 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6376d0f978c75fa7c4f23ee6e24905dbTest http://europepmc.org/articles/PMC5416925Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6376d0f978c75fa7c4f23ee6e24905db |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22886796 22886575 |
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