دورية أكاديمية
Prediction of renal recovery following sepsis-associated acute kidney injury requiring renal replacement therapy using contrast-enhanced ultrasonography
| العنوان: | Prediction of renal recovery following sepsis-associated acute kidney injury requiring renal replacement therapy using contrast-enhanced ultrasonography |
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| المؤلفون: | Jungho Shin, Jin Ho Hwang, Sung Bin Park, Su Hyun Kim |
| المصدر: | Kidney Research and Clinical Practice, Vol 42, Iss 4, Pp 473-486 (2023) |
| بيانات النشر: | The Korean Society of Nephrology, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Internal medicine LCC:Specialties of internal medicine |
| مصطلحات موضوعية: | acute kidney injury, microcirculation, renal recovery, renal replacement therapy, sepsis, Internal medicine, RC31-1245, Specialties of internal medicine, RC581-951 |
| الوصف: | Background Microcirculatory dysfunction plays a critical role in sepsis-associated acute kidney injury (S-AKI) development; however, its impact on renal recovery remains uncertain. We investigated the association between cortical microcirculatory function assessed using contrast-enhanced ultrasonography (CEUS) and renal recovery after S-AKI needing renal replacement therapy (RRT). Methods This retrospective study included 23 patients who underwent CEUS among those who underwent acute RRT for S-AKI. In addition, we acquired data from 17 healthy individuals and 18 patients with chronic kidney disease. Renal recovery was defined as sustained independence from RRT for at least 14 days. Results Of the CEUS-derived parameters, rise time, time to peak, and fall time were longer in patients with S-AKI than in healthy individuals (p = 0.045, 0.01, and 0.096, respectively). Fourteen patients (60.9%) with S-AKI receiving RRT experienced renal recovery; and these patients had higher values of peak enhancement, wash-in area under the curve (AUC), wash-in perfusion index, and wash-out AUC than those without recovery (p = 0.03, 0.01, 0.03, and 0.046, respectively). We evaluated the receiver operating characteristic curve and found that the peak enhancement, wash-in AUC, wash-in perfusion index, and wash-out AUC of CEUS derivatives estimated the probability of renal recovery after S-AKI requiring RRT (p = 0.03, 0.01, 0.03, and 0.04, respectively). Conclusion CEUS-assessed cortical microvascular perfusion may predict renal recovery following S-AKI that requires RRT. Further studies are essential to validate the clinical utility of microcirculatory parameters obtained from CEUS to estimate renal outcomes in various etiologies and severities of kidney disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Korean |
| تدمد: | 2211-9132 2211-9140 |
| العلاقة: | http://www.krcp-ksn.org/upload/pdf/j-krcp-22-086.pdfTest; https://doaj.org/toc/2211-9132Test; https://doaj.org/toc/2211-9140Test |
| DOI: | 10.23876/j.krcp.22.086 |
| الوصول الحر: | https://doaj.org/article/76d04ebcf69a4f798b6bfaea6eea87e1Test |
| رقم الانضمام: | edsdoj.76d04ebcf69a4f798b6bfaea6eea87e1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22119132 22119140 |
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| DOI: | 10.23876/j.krcp.22.086 |